Emotions, Dopamine, Brain and Body

Phase 4

Recruiting

• Conditions: Emotions
• Interventions: Drug: Domperidon; Drug: Placebo

• Registration Number: NCT06171087
• Lead Sponsor: German Institute of Human Nutrition

Brief Summary

The study will examine the influence of domperidon (20mg) on brain and hebavioral responses to emotional stimuli (videos) using fMRI

Detailed Description

Not available

Study Timeline

• Study Start: 2023-08-01
• Status Verified: 2023-12
• Study First Submitted: 2023-12-06
• Study First Submitted QC: 2023-12-06
• Last Update Submitted: 2023-12-06
• Study First Posted: 2023-12-14
• Last Update Posted: 2023-12-14
• Primary Completion: 2024-03-30
• Study Completion: 2024-09-30

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

Not provided

Exclusion Criteria

Not provided

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SEQUENTIAL

Arm && Interventions

Group	Intervention	Description
Domperidon	Domperidon	Participants recieve 10mg of Domperidon, 45 minutes before the start of the experiment
Placebo	Placebo	Participants recieve a placebo pill, 45 minutes before the start of the experiment

Primary Outcome Measures

Name	Time	Method
Brain responses to emotions	1-3 hour after drug administratrion	fMRI brain responses to emotional videos comparing placebo vs domperidon condition. Specifically: dampened brain response to disgust and high arousing videos in domperidon condition
Body (stomach, heart, skin conductance) response to emotions	1-3 hour after drug administratrion	Physiological responses to emotional videos comparing placebo vs domperidon condition. Specifically: Reduction in Tachyhastria for disgust and high arousing videos in domperidone condition
Behavioral responses to emotions	1-3 hour after drug administratrion	Changes in subjective reports to emotional videos comparing placebo vs domperidon condition. Specifically: Reduction in disgust and arousal ratings to disgust and high arousing videos

Trial Locations

Locations (1)

German Institute of Human Nutrition; 🇩🇪 Potsdam, Brandenburg, Germany