Influence of Domperidon on the Experience of Emotions, Brain and Bodily Activity
Trial Snapshot
- Phase
- Phase 4
- Status
- Recruiting
- Enrollment
- 40
- Locations
- 1
- Primary Endpoint
- Brain responses to emotions
Study Overview
Brief Summary
The study will examine the influence of domperidon (20mg) on brain and hebavioral responses to emotional stimuli (videos) using fMRI
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Sequential
- Primary Purpose
- Basic Science
- Masking
- Triple (Participant, Investigator, Outcomes Assessor)
Eligibility Criteria
- Ages
- 18 Years to 40 Years (Adult)
- Sex
- All
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- Not provided
Exclusion Criteria
- Not provided
Arms & Interventions
Domperidon
Participants recieve 10mg of Domperidon, 45 minutes before the start of the experiment
Intervention: Domperidon (Drug)
Placebo
Participants recieve a placebo pill, 45 minutes before the start of the experiment
Intervention: Placebo (Drug)
Outcomes
Primary Outcomes
Brain responses to emotions
Time Frame: 1-3 hour after drug administratrion
fMRI brain responses to emotional videos comparing placebo vs domperidon condition. Specifically: dampened brain response to disgust and high arousing videos in domperidon condition
Body (stomach, heart, skin conductance) response to emotions
Time Frame: 1-3 hour after drug administratrion
Physiological responses to emotional videos comparing placebo vs domperidon condition. Specifically: Reduction in Tachyhastria for disgust and high arousing videos in domperidone condition
Behavioral responses to emotions
Time Frame: 1-3 hour after drug administratrion
Changes in subjective reports to emotional videos comparing placebo vs domperidon condition. Specifically: Reduction in disgust and arousal ratings to disgust and high arousing videos
Secondary Outcomes
No secondary outcomes reported
Investigators
Prof. Dr. Soyoung Q Park
Prof. Dr.
German Institute of Human Nutrition