Anesthesia During Neurophysiologic Monitoring in Scoliosis Patients

Not Applicable

Completed

• Conditions: Idiopathic Scoliosis
• Interventions: Drug: propofol; Drug: Desflurane

• Registration Number: NCT01549873
• Lead Sponsor: Nationwide Children's Hospital

Brief Summary

When patients have spinal surgery, electrodes are placed on the body to measure motor evoked potentials (MEP) and somatosensory evoked potentials (SSEP). Many hospitals only use IV anesthesia because they feel that measuring MEP and SSEP is easier using IV anesthesia. At this hospital the investigators typically use inhaled anesthesia and are able to successfully measure MEP and SSEP. This is a study to find out if one method of anesthesia is better than the other for measuring MEP and SSEP.

Detailed Description

Not available

Study Timeline

• Study Start: 2012-01
• Study First Submitted: 2012-03-07
• Study First Submitted QC: 2012-03-08
• Study First Posted: 2012-03-09
• Primary Completion: 2013-04
• Study Completion: 2013-06
• Status Verified: 2015-02
• Results First Submitted: 2015-02-04
• Results First Submitted QC: 2015-02-24
• Last Update Submitted: 2015-02-24
• Results First Posted: 2015-02-26
• Last Update Posted: 2015-02-26

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

• Patients with idiopathic scoliosis.

Exclusion Criteria

• Patients with neuromuscular scoliosis.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Total intravenous anesthesia (TIVA)	propofol	-
Inhaled anesthesia	Desflurane	-

Primary Outcome Measures

Name	Time	Method
Amplitude Required to Elicit the MEP	at time of surgery	Compare the data obtained from neuromonitoring including the amplitude required to elicit the MEP from patients receiving general anesthesia with an inhalational anesthetic agent to those receiving total intravenous anesthesia (TIVA).

Secondary Outcome Measures

Name	Time	Method
Amplitude of the SSEPs	day of surgery	SSEPs (somatosensory evoked potentials) are most commonly elicited by bipolar transcutaneous electrical stimulation applied on the skin over the trajectory of peripheral nerves of the upper limb (e.g., the median nerve) or lower limb (e.g., the posterior tibial nerve), and then recorded from the scalp. The amplitude is the voltage of the electrical stimulation recorded.
Latency of the SSEP's	day of surgery	SSEPs (somatosensory evoked potentials) are most commonly elicited by bipolar transcutaneous electrical stimulation applied on the skin over the trajectory of peripheral nerves of the upper limb (e.g., the median nerve) or lower limb (e.g., the posterior tibial nerve), and then recorded from the scalp. Latency is the time interval between the stimulation and response.

Trial Locations

Locations (1)

Nationwide Children's Hospital; 🇺🇸 Columbus, Ohio, United States