Observational Study of HIV-Infected Subjects With X4-Tropic or Non-Phenotypeable Virus

Terminated

Brief Summary: The purpose of this study is to measure viral tropism over time in subjects with X4-tropic or non-phenotypeable virus while receiving standard of care therapy. This is an observational study. No investigational treatment will be administered through this study.

Recruitment & Eligibility

Inclusion Criteria

HIV-infected.
Screening viral load at least 5000copies/mL.
X4-tropic only or non-phenotypeable virus at screening.
Total prior antiretroviral experience of at least 3 months and documented resistance to at least one drug in each of the following classes: NRTI, NNRTI, and PI, stable antiretroviral regimen (or no antiretroviral treatment) for at least 4 weeks before screening.
Able to receive a ritonavir-boosted protease inhibitor during treatment studies.
Women of childbearing potential must use specific forms of contraception.

Exclusion criteria:

R5-tropic only or R5/X4-tropic virus at screening, changes to antiretroviral therapy from 4 weeks prior to screening until Day 1 of observational study.
Pregnant or breastfeeding women.
Significant ECG abnormalities or significant history of active pancreatitis, hepatitis, opportunistic infections, cancer, or severe illness.
Current use of certain medications may exclude participation in this study.
Additional qualifying criteria and laboratory test requirements to be determined by study physician.

Primary Outcome Measures

Name	Time	Method

Secondary Outcome Measures

Name	Time	Method