Total Intravenous Anesthesia Versus Inhalation Anesthesia on Postoperative Liver Function

Not Applicable

Completed

• Conditions: Laparoscopic Sleeve Gastrectomy
• Interventions: Drug: sevoflurane group; Drug: Total intravenous anesthesia group

• Registration Number: NCT06423846
• Lead Sponsor: Benha University

Brief Summary

The pandemic of obesity has become a serious issue of public health worldwide as the size of the obese population has almost tripled over the last four decades and continues to riseزThe epidemic of obesity has led to a significant increase in the prevalence of non-alcoholic fatty liver disease (NAFLD). NAFLD is currently the most common chronic liver disease, with an estimated global prevalence at 25-30%, rising up to 90% in morbidly obese patients

Detailed Description

Anesthesia and surgery may deteriorate liver function in patients with elevated liver enzyme levels; therefore, in these patients, choosing anaesthetics with less hepatotoxicity may be important. Halothane, which is a typical inhalational anesthetic, is known for its liver and kidney toxicity. The latest anesthetic agents, including sevoflurane and desflurane, are associated with less hepatotoxicity, although rare cases of acute liver injury have been reported with these agentsزPropofol (2,6-diisopropylphenol) is an intravenous anesthetic. Its pharmacokinetic profile makes it very suitable for total intravenous anesthesia (TIVA) and this is a widely used technique in many centers. Its use results in a rapid onset and offset with fewer side effects including postoperative nausea and vomiting, making it particularly favorable in the ambulatory setting

Study Timeline

• Study Start: 2024-01-26
• Status Verified: 2024-05
• Primary Completion: 2024-05-06
• Study Completion: 2024-05-12
• Study First Submitted: 2024-05-16
• Study First Submitted QC: 2024-05-16
• Last Update Submitted: 2024-05-16
• Study First Posted: 2024-05-21
• Last Update Posted: 2024-05-21

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 80

Inclusion Criteria

• Obese patients
• had ASA I-III
• diagnosed with non-alcoholic steatohepatitis (NASH) liver disease
• undergoing laparoscopic sleeve gastrectomy

Exclusion Criteria

• cases wherein surgeries were performed using anesthetic methods that were not clearly identified as TIVA or INHA
• heart surgery or cesarean section, and cases of neuromuscular diseases

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
sevoflurane group	sevoflurane group	general anesthesia was induced with propofol 2 mg/kg, fentanyl 1 ug/kg and then maintained with sevoflurane in air and oxygen, dexmedetomidine 1 ug/kg/hour.
total intravenous anesthesia group	Total intravenous anesthesia group	Patients in the TIVA group had anesthesia induced with propofol 2 mg/kg , fentanyl 1 ug/kg and maintained with propofol.

Primary Outcome Measures

Name	Time	Method
visual analogue scale	visual analogue scale was measured at day one and day two postoperatively	Pain was assessed by using the visual analogue scale (VAS) score for pain (0-no pain, 10-worst imaginable pain)

Secondary Outcome Measures

Name	Time	Method
Patient satisfaction	24 hours postoperatively	5-point Likert scale, (1=extremely dissatisfied; 5=extremely satisfied)

Trial Locations

Locations (1)

Benha University; 🇪🇬 Banha, Egypt