Assessment of Ventilation-perfusion Abnormalities in Patients With Stable Smoking-related Airways Disease

Not Applicable

Terminated

• Conditions: Chronic Obstructive Pulmonary Disease
• Interventions: Drug: nebulized saline; Drug: salbutamol + ipratropium bromide nebules

• Registration Number: NCT00180843
• Lead Sponsor: Imperial College London

Brief Summary

Subjects undergo history, examination, lung function assessment after informed consent has been obtained. All subjects will undergo ventilation-perfusion scans. If there first scan is normal they will undergo a second and final scan four weeks later. If abnormal they will undergo two further scans with either nebulized bronchodilator or nebulized saline prior to their second and third scans. Each time they will have repeat lung function tests prior to scanning. We will examine the regional changes in ventilation and perfusion and there relationship to lung function.

Detailed Description

As in Brief description

Study Timeline

• Study Start: 2005-09
• Study First Submitted: 2005-09-13
• Study First Submitted QC: 2005-09-13
• Study First Posted: 2005-09-16
• Primary Completion: 2008-02
• Study Completion: 2008-02
• Status Verified: 2013-09
• Last Update Submitted: 2013-09-21
• Last Update Posted: 2013-09-24

Recruitment & Eligibility

• Status: TERMINATED
• Sex: All
• Target Recruitment: 2

Inclusion Criteria

• FEV1 < 70% predicted at baseline on spirometry
• significant smoking history or alpha 1 antitrypsin deficiency
• no evidence of current infection or restrictive lung disease

Exclusion Criteria

• history of other significant respiratory disease
• significant respiratory infection within 6 weeks
• history of significant physical or mental illness rendering them unfit for the study in the opinion of the investigator
• taken part in any other research within the past 12 months, or received exposure to ionizing radiation

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
saline control	nebulized saline	nebulized saline
salbutamol and ipratropium bromide nebules	salbutamol + ipratropium bromide nebules	salbutamol 2.5 mg and ipratropium bromide 0.5 mg

Primary Outcome Measures

Name	Time	Method
scan grade	post scan	previously validated grading score

Secondary Outcome Measures

Name	Time	Method
lung function	pre scan

Trial Locations

Locations (1)

Imperial College Hammersmith Campus; 🇬🇧 London, United Kingdom