NCT03401814
Completed
Not Applicable
Imaging Response to Immunotherapy and Radiation Therapy in Patients With Liver Metastases
ConditionsLiver Metastases
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Liver Metastases
- Sponsor
- Mayo Clinic
- Enrollment
- 1
- Locations
- 1
- Primary Endpoint
- Quantify tissue mechanical properties of the liver and liver tumor using MRE in patients receiving radiation therapy + immunotherapy at baseline, mid-treatment and time of followup imaging determined by standard of care to assess response to therapy
- Status
- Completed
- Last Updated
- 4 years ago
Overview
Brief Summary
Patients will be imaged with MRE at the time of the RT planning MRI, prior to the induction of RT and immunotherapy. Research imaging will be in addition to standard imaging studies performed at time points consistent with the standard of care (at the time of the RT planning MRI and the first clinical follow-up). An additional MRE exam will be performed at the end of treatment outside the standard of care imaging.
Investigators
Sean S. Park
Radiation Oncology Consultant
Mayo Clinic
Eligibility Criteria
Inclusion Criteria
- •Age ≥ 18 years
- •Diagnosis of solid cancers with the presence of one or more liver metastases
- •Minimum metastasis diameter ≥ 2 cm
- •Planning to receive radiation therapy with immunotherapy
- •Willingness to participate in mandatory imaging studies at Mayo Clinic Rochester
Exclusion Criteria
- •Contraindications for MRI including claustrophobia, pace maker, metal implants, aneurism clips
- •Patients who are not able to consent
Outcomes
Primary Outcomes
Quantify tissue mechanical properties of the liver and liver tumor using MRE in patients receiving radiation therapy + immunotherapy at baseline, mid-treatment and time of followup imaging determined by standard of care to assess response to therapy
Time Frame: 1 year
Study Sites (1)
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