Imaging Response to Immunotherapy and Radiation Therapy in Patients With Liver Metastases

Completed

• Conditions: Liver Metastases

• Registration Number: NCT03401814
• Lead Sponsor: Mayo Clinic

Brief Summary

Patients will be imaged with MRE at the time of the RT planning MRI, prior to the induction of RT and immunotherapy. Research imaging will be in addition to standard imaging studies performed at time points consistent with the standard of care (at the time of the RT planning MRI and the first clinical follow-up). An additional MRE exam will be performed at the end of treatment outside the standard of care imaging.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2018-01-10
• Study First Submitted QC: 2018-01-10
• Study First Posted: 2018-01-17
• Study Start: 2018-08-02
• Primary Completion: 2019-12-12
• Study Completion: 2019-12-12
• Status Verified: 2021-07
• Last Update Submitted: 2021-07-08
• Last Update Posted: 2021-07-09

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 1

Inclusion Criteria

• Age ≥ 18 years
• Diagnosis of solid cancers with the presence of one or more liver metastases
• Minimum metastasis diameter ≥ 2 cm
• Planning to receive radiation therapy with immunotherapy
• Willingness to participate in mandatory imaging studies at Mayo Clinic Rochester

Exclusion Criteria

• Contraindications for MRI including claustrophobia, pace maker, metal implants, aneurism clips
• Patients who are not able to consent

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Quantify tissue mechanical properties of the liver and liver tumor using MRE in patients receiving radiation therapy + immunotherapy at baseline, mid-treatment and time of followup imaging determined by standard of care to assess response to therapy	1 year

Trial Locations

Locations (1)

Mayo Clinic; 🇺🇸 Rochester, Minnesota, United States