Effects of Mirror Neurons Stimulation on Motor Skill Rehabilitation in Children With Cerebral Palsy

Not Applicable

Completed

• Conditions: Children With Spastic Diplegia, Between the Ages of 2 to 10 Years; Gross Motor Function Classification System (GMFCS) Level I,II and III
• Interventions: Procedure: The mirror neurons stimulation based VCD program; Procedure: The conventional physical therapy

• Registration Number: NCT01267929
• Lead Sponsor: Thammasat University

Brief Summary

This study aimed to develop Video Compact Disc (VCD) program that applying the concept of imitative learning with mirror neurons stimulation on standard rehabilitation technique in children with cerebral palsy. The author will also examine effectiveness of the program by compare the motor function measured by the gross motor function measure (GMFM-66) between conventional physical therapy and the mirror neurons stimulation based VCD program for six months.

Detailed Description

A randomized controlled trial was performed with thirty children with cerebral palsy recruited from Thammasat University Hospital and Rajanukul institute. Informed consent was obtained from the participants' parents before participation in this study. The participants were randomly assigned according to the randomization list to receive either the mirror neurons stimulation based VCD program and practice at home or conventional physical therapy for six months. The participants in the experiment group received the mirror neurons stimulation based VCD program and practice at home three times a day for six months. Concerning the control group, the participants received conventional physical therapy regularly at the hospital once a week for first two months and twice a month for last four months. Both experimental and control groups were measured their motor functions with gross motor function measure (GMFM-66).

Study Timeline

• Study Start: 2009-09
• Study First Submitted: 2010-12-28
• Study First Submitted QC: 2010-12-28
• Study First Posted: 2010-12-29
• Primary Completion: 2011-08
• Study Completion: 2011-10
• Results First Submitted: 2012-03-05
• Results First Submitted QC: 2014-01-17
• Results First Posted: 2014-02-17
• Status Verified: 2017-11
• Last Update Submitted: 2017-11-10
• Last Update Posted: 2017-12-18

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

• Children with cerebral palsy aged between 2-10 years old
• GMFCS level of one to three
• Able to verbal instruction
• Sitting are performed without assistance
• Standing and walking are performed with adult assistance
• No severe limitation of joint movement

Exclusion Criteria

• The children were received orthopedic intervention or botulinum toxin injection within 6 months
• Seizure
• Other conditions that prevent children from participate in research project
• Severe visual and hearing deficits

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
The mirror neurons stimulation based VCD program	The mirror neurons stimulation based VCD program	The children receive the mirror neurons stimulation based VCD program and practice at home three times a day for six months. The mirror neurons stimulation based VCD program that contained four volumes. The first volume includes activities activities for improving balance in sitting position. The second volume includes activities of sitting to standing. The third volume includes activities for improving balance in standing position. The last one includes activities of sideway walking. The running time of each volume is 30 minutes. The children had been practicing for two weeks per volume. Their parents were trained for practicing their children by VCD program at home and were asked to complete daily record of children's activities. The children were scheduled to meet a pediatric physical therapist once a week to monitor possible side effects.
The conventional physical therapy	The conventional physical therapy	The children receive manual physical therapy regularly at the hospital once a week for first two months and twice a month for last four months. The conventional physical therapy technique in this study derive from the manual technique including the Bobath concept, stretching exercise and functional training for 30-45 minutes at a time.

Primary Outcome Measures

Name	Time	Method
The Gross Motor Function Measure (GMFM-66) Score at Entry, the Second and the Sixth Month.	Base line, two months and six months	The mean total score of GMFM-66 of each group at entry, the second and the sixth month. The GMFM-66 contains five dimensions of motor measure including lying/rolling (4 items), sitting (15 items), crawling/kneeling (10 items), standing (13 items), and walking/running/jumping (24 items). The GMFM-66 are scored on a 4-point ordinal scale 0=does not initiate, 1=initiates \< 10% of activity,2=partially completes 10% to \< 100% of activity,3=completes activity). The scores were converted to a continuous scale by using the Winsteps Rasch Software.The GMFM-66 score is an interval-level measure of function where subjects are placed on an ability continuum ranging from 0 (low motor ability) to 100 (high motor ability). GMFM-66 score less than 30 that are considered low gross motor skills.

Trial Locations

Locations (1)

Department of Physical therapy, Faculty of Allied Health Sciences Thammasat University; 🇹🇭 Pathumthani, Thailand