The variations in small vascular wall function during the menstrual cycle in young healthy women.

• Conditions: het betreft geen aandoening er wordt gekeken naar de vaatfunctie in de cyclus van gezonde vrouwen; nvt

• Registration Number: NL-OMON30179
• Lead Sponsor: Academisch Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 18 June 2024

Recruitment & Eligibility

• Status: Pending
• Sex: Not specified
• Target Recruitment: 16

Inclusion Criteria

- Healthy as judged by history and physical examination
- Regular ovulatory menstrual cycles between 21- 35 days (proven by biphasic BTC or midluteal progesterone > 10 nmol/l)
-18- 35 years
- no medication including oral conceptive or hormonal intra- uterine device (IUD) for at least three months

Exclusion Criteria

- Cardiovascular disease (hypertension (>160/90 mmHg), stroke, coronary artery disease,peripheral vascular disease, heart failure)
-Diabetes mellitus (according to ADA criteria )
-Smoking for the last three months
-Alcohol use > 4U/day
-Diseases that influence reproductive hormone status

Study & Design

• Study Type: Observational non invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>- cycle dependent microvascular function<br /><br>- microvascular function is measured in three different ways:<br /><br>1. capillary refill (with the microscope)<br /><br>2. endothelial dependent and independent vasodilatation (iontophoresis)<br /><br>3. insulin dependent vasodilation<br /><br>4. vasomotion</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>nvt</p><br>