Myocardial Injury following Coronary Artery bypass Surgery versus percutaneous coronary Angioplasty with stents: a randomised controlled trial using biochemical markers and cardiovascular magnetic resonance imaging
Completed
- Conditions
- Circulatory SystemCoronary artery diseaseMultivessel coronary artery disease
- Registration Number
- ISRCTN25699844
- Lead Sponsor
- Oxford Radcliffe Hospitals NHS Trust (UK)
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 60
Inclusion Criteria
1. Patients with greater than or equal to two vessel CAD (greater than or equal to 50% stenosis) including the Left Anterior Descending (LAD), and/or a functionally significant left main stem stenosis of 50% or more
2. Equivalent revascularisation can be provided by PCI and CABG
3. Angina (stable or unstable), or documented silent ischaemia on functional stress testing
Exclusion Criteria
1. Contraindication to aspirin or clopidogrel
2. Women of childbearing potential
3. Non-viable myocardium in the area subtended by diseased vessels
4. Patients requiring concomitant cardiac surgery
5. Acute myocardial infarction
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The frequency of new myocardial injury following PCI and CABG as assessed by biochemical markers (troponin I) and MRI.
- Secondary Outcome Measures
Name Time Method 1. Total amount of new myocardial necrosis (in grams) assessed by MRI<br>2. Change in left ventricular function assessed by MRI