Characterization of Post Coronary Artery Bypass Grafting Atrial Fibrillation Patterns

Conditions: I48.0
Paroxysmal atrial fibrillation

Registration Number: DRKS00018887

Lead Sponsor: Klinikum der Universität München, Campus Großhadern

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Complete

Sex: All

Target Recruitment: 198

Inclusion Criteria

1. Three vessel coronary artery disease or left mainstem disease
2. = 2 coronary artery bypass grafts performed
3. Preoperative left ventricular ejection fraction = 35 %
4. Preoperative sinus rhythm
5. Age > 18 years

Exclusion Criteria

1. Any history of atrial fibrillation, atrial flutter or atrial tachycardia
2. Any history of the following complex rhythm disorders:
I. Sinoatrial block
II. Sick sinus syndrome
III. Atrioventricular block > Grade 1
IV. AV node reentry tachycardia
V. AV reentry tachycardia
VI. Focal atrial tachycardia
VII. Accelerated junctional rhythm
VIII. Ventricular tachycardia
IX. Ventricular fibrillation
X. Long-QT syndrome
3. Valvular heart disease
4. Concurrent cardiac surgery (valve surgery, aortic surgery, surgical ablation)
5. Pre- or postoperative mechanical circulatory support (failure to wean from cardiopulmonary
bypass machine / intraaortic balloon pump / extracorporeal membrane oxygenation /
Impella® device)
6. Repeat cardiac surgery
7. LVEF < 35 %
8. Age = 18 years
9. Life expectancy < 1 year
10. Doubtful patient compliance

Study & Design

Study Type: observational

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Incidence of atrial fibrillation 12 months after coronary artery bypass grafting surgery

Secondary Outcome Measures

Name	Time	Method
- Atrial fibrillation burden within the first 12 months after surgery<br>- Atrial fibrillation density within the first 12 months after surgery<br>- Ratio of silent to symptomatic atrial fibrillation episodes in the first 12 months after surgery<br>- Sinus arrest > 6 seconds within the first 12 months after surgery<br>- Higher degree atrioventricular block = IIa within the first 12 months after surgery<br>- Incidence of ischemic stroke in the first 12 months after surgery<br>- All-cause mortality at 12 months<br>- Cardiovascular mortality at 12 months<br>- Major Adverse Cardiovascular Events at 12 months<br>- Quality of life at 3 and 12 months (as compared to preoperatively)