Inflammation markers, blood oxidative stress and working memory capacity in patients with GHB use disorder undergoing detoxificatio

• Conditions: GHB addiction; GHB use disorder; 10037176

• Registration Number: NL-OMON51379
• Lead Sponsor: Radboud Universitair Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 15 April 2024

Recruitment & Eligibility

• Status: Pending
• Sex: Not specified
• Target Recruitment: 33

Inclusion Criteria

• Diagnosed with a GHB use disorder according to the DSM V
• Undergoing GHB detoxification through pharmaceutical GHB titration and
tapering
• 18 years or older

Exclusion Criteria

• Patient who have acute psychiatric co-morbidity that require immediate
medical attention and interferes with the execution of the study, such as
mania, delirium and psychosis
• Insufficient understanding of the Dutch language
• Patients with a phobia of needles
• Patient is pregnant (this will be checked upon admission as a part of the
regular treatment protocol)

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Cytokines IL-6, IL-8, IL-10, TNF-a, and oxidative stress markers<br /><br>malondialdehyde (MDA), catalase (CAT), glutathione peroxidase (GPX), superoxide<br /><br>dismutase (SOD) and 8-OHdG</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Results on the cognitive tasks digit span task and corsi block tapping tasks.</p><br>