Optimum dose finding study of 0.75% hyperbaric ropivacaine for unilateral subarachnoid block in lower limb orthopedic surgeries

Not yet recruiting

• Conditions: Medical and Surgical,

• Registration Number: CTRI/2022/09/045396
• Lead Sponsor: Department of Anesthesiology

Brief Summary

Subarachnoid block is one of the important techniques of anesthesia for performing orthopedic lower limb surgeries as it can produce adequate sensory, motor and sympathetic block in a rapid manner. This can become more cost effective with unilateral block as hemodynamic effects, post operative urinary retention can be minimized leading to better patient satisfaction and faster discharge. Ropivacaine is an alternative to bupivacaine for subarachnoid block as it has less chance of cardiotoxicity as well as neurotoxicity. Although 0.5% Ropivacaine in isobaric or hyperbaric form has been used in lower limb surgeries , very less information is available regarding 0.75% Ropivacaine for unilateral block for orthopedic lower limb surgeries. The ideal dose of 0.75% ropivacaine for unilateral subarachnoid block for this type of orthopedic surgeries can be ascertained by assessing the maximum and minimum sensory and motor block on the operative and nonoperative sides and its effect on hemodynamics.

Detailed Description

Not available

Study Timeline

• Last Update Posted: 2022-08-09
• Study Start: 2022-09-15

Recruitment & Eligibility

• Status: Not Yet Recruiting
• Sex: All
• Target Recruitment: 102

Inclusion Criteria

• Body weight.
• 40-85 kg Height.
• 150-180 cm ASA 1, 2 Duration of surgery.
• less than 1 hour.

Exclusion Criteria

Unwilling for subarachnoid block, skin infection at the site of intrathecal injection, allergy to the study drug, coagulopathy, taking anticoagulant drugs, hypovolemia, fixed cardiac output disease, undetermined neurologic disease, spine deformity.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
To determine the ideal dosage of hyperbaric 0.75% ropivacaine for unilateral subarachnoid block in orthopedic lower limb surgeries by assessing the maximum sensory and motor block o both operative and non operative sides by each individual dosage	baseline, 20 minutes after the injection for subarachnoid block, 2 hours after the sbaracoid block

Secondary Outcome Measures

Name	Time	Method
hemodynamic effects of the 3 different doses for unilateral subarachnoid block	during the surgery

Trial Locations

Locations (1)

Operation theatre of Superspeciality hospital (SSH) builiding; 🇮🇳 Parganas, WEST BENGAL, India

Operation theatre of Superspeciality hospital (SSH) builiding

🇮🇳Parganas, WEST BENGAL, India

Dr Suchismita Pal

Principal investigator

9474599093

suchiofficial21@gmail.com