Impaired cerebral autoregulation in patients with sickle cell disease

• Conditions: sickle cell disease; 10018902

• Registration Number: NL-OMON29798
• Lead Sponsor: Academisch Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 13 May 2024

Recruitment & Eligibility

• Status: Pending
• Sex: Not specified
• Target Recruitment: 20

Inclusion Criteria

- proven sickle cell disease
- age between 18-35

Exclusion Criteria

- HbSC
- History of stroke
- Hypertension (systolic >160 mm Hg or diastolic >100 mm Hg)
- Blood transfusion in the preceding four weeks
- Sickle cell crisis in the preceding two weeks

Study & Design

• Study Type: Observational non invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Cerebral blood flow velocity, cerebral oxygenation and cerebrovascular CO2<br /><br>responsiveness (as the percentage increase in MCA Vmean per mmHg increase in<br /><br>PetCO2). </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Autonomic cardiovascular function (blood pressure, cardiac output and derived<br /><br>parameters)testing using the Ewing*s test battery (a set of short physical<br /><br>exercises: e.g. vassalva maneuver and deep breathing) is used to measure<br /><br>parasympathetic heart rate control, sympathetic cardiovascular control.</p><br>