Pain-related learning and memory processes in women with endometriosis

Recruiting

Conditions: N80
Endometriosis

Registration Number: DRKS00033676

Lead Sponsor: Abteilung für Medizinische Psychologie und Medizinische Soziologie

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Recruiting

Sex: Female

Target Recruitment: 100

Inclusion Criteria

All participants: BMI 18-30 kg/m2; hormonal contraception
Patients additionally: confirmed diagnosis of endometriosis

Exclusion Criteria

Patients: severe acute / organic psychiatric illnesses, neurological or oncological diseases; diabetes mellitus, increased bleeding tendency, regular use of opioids or neuromodulators.
Healthy participants: any mental or physical illness, especially pain, urogenital/gynecological symptoms or gastrointestinal symptoms and regular use of medication (except hormonal contraceptives).
All participants: MRI-relevant exclusion criteria (e.g. claustrophobia, ferromagnetic implants), evidence of substance abuse; changes in the anorectal area; pregnancy or breastfeeding.

Study & Design

Study Type: observational

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Valence and fear ratings of predictive cues assessed using visual analog scales (VAS); electrodermal activity (EDA) as a psychophysiological response.

Secondary Outcome Measures

Name	Time	Method
Evaluation of the valence and intensity of acoustic stimuli and pain stimuli (VAS); state anxiety (questionnaire), salivary concentrations of cortisol and alpha-amylase (neuroendocrine stress markers); analysis of changes in the electrogastrogram signal (EGG), blood pressure and heart rate variability (HRV) (indirect measures of autonomic responses and arousal); cytokines IL-6, IL-8 and TNF-alpha as well as the acute-phase proteins C-reactive protein (CRP) and serum amyloid A (SAA) for the detection of (sub-)clinical inflammation.