Effects of catecholamines on memory retention; an exploratory study

Completed

• Conditions: fundamental cognitive neuroscience research of memory consolidation and retention with possible future implications in psychopharmacy and treatment for patients with memory deficits; long-term memory; memory consolidation

• Registration Number: NL-OMON41056
• Lead Sponsor: Radboud Universiteit Nijmegen

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 23 April 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 60

Inclusion Criteria

Healthy right-handed male volunteers between 18 and 35 of age. Normal or corrected-to-normal vision and willingness and ability to sign informed consent

Exclusion Criteria

• (History of) psychiatric treatment
• (History of) neurological treatment
• (History of) endocrine treatment
• (History of) autonomic failure (e.g., vasovagal reflex syncope).
• (History of) clinically significant hepatic, cardiac, obstructive respiratory, renal, cerebrovascular, metabolic or pulmonary disease
• Family history of sudden death or ventricular arrhythmia
• (History of) epilepsy
• (History of) drug dependence (opiate, LSD, (meth)amphetamine, cocaine, solvents, or barbiturate) or alcohol dependence
• Family history of schizophrenia or bipolar disorder
• Current or past use of psychotropic medication
• Regular use of corticosteroids.
• Suicidality
• Diabetes
• Uncontrolled hypertension, defined as diastolic blood pressure at rest > 95 mmHg or systolic blood pressure at rest > 180 mmHg
• Hypotension, defined as diastolic blood pressure < 50 mm Hg or systolic < 95 mm Hg or resting pulse rate < 45 beats/min
• Abnormal hearing or (uncorrected) vision.
• Lactose intolerance (placebo pill is a lactose product)
• Irregular sleep/wake rhythm (e.g., regular nightshifts or cross timeline travel).
• Current use of oral medication aside from occasional use of paracetamol
• Use of recreational drugs or alcohol over a period of 24 hours prior to the first study day
• Subjects with any personal characteristics that make him/her ineligible for MR scanning

Study & Design

• Study Type: Interventional
• Study Design: Not specified