Psychopathology, Disordered Eating, and Impulsivity as Predictors of Outcomes of Bariatric Surgery

Psychosocial Status and Psychopathology in Candidates for Bariatric Surgery:

Extreme obesity is associated with a significant psychosocial burden, including impairments in quality of life, body image, sexual behavior and other areas of psychosocial functioning. While this distress is believed to contribute to the decision to have bariatric surgery, its impact on postoperative outcomes is less clear. At present, little is known about the physiological and behavioral contributions to success or failure of bariatric surgery. Regardless, weight regain after bariatric surgery is frequently attributed to preoperative psychosocial and behavioral factors. More specifically, there has been a great deal of interest in the presence of formal psychopathology in bariatric surgery patients and its potential contribution to postoperative outcomes. At least six studies have described rates of psychopathology in candidates for bariatric surgery using structured diagnostic instruments. Lifetime rates of any psychiatric diagnoses ranged from 36.8%-72.6%, higher than those reported in most studies of the general population. Mood disorders were the most frequent diagnoses, seen in 22.0%-54.8% of patients. Substance use disorders (SUDs) were found in up to 35.7% of patients and alcohol abuse or dependence in up to 33.2%. Binge eating disorder (BED), defined as eating an unusually large amount of food within a short period of time coupled with a loss of control over eating, has been diagnosed in 4.6% to 27.1% of patients. Current diagnoses (as compared with lifetime) were less common, reported in 20.9%-55.5% of candidates for surgery. Mood disorders were diagnosed in up to 31.5%. BED ranged from 3.4%-41.9%. Current substance use was seen in less than 2% of patients. (Note. The lower percentages of those with current psychopathology, as opposed to lifetime psychopathology, are expected.) While studies of the psychosocial characteristics of bariatric surgery candidates have been informative, they are not without limitations. Many studies have suffered from methodological concerns, including small sample sizes or lack of an appropriate comparison group. Further, establishing psychiatric diagnoses prior to bariatric surgery is challenging. Perioperative guidelines suggest that patients undergo an evaluation with a mental health professional prior to surgery and most third party payers require these evaluations. However, most programs do not use structured clinical interviews to establish diagnoses for clinical purposes. Several studies have suggested that candidates for bariatric surgery engage in impression management prior to surgery, in which they minimize reports of psychopathology to present themselves to the bariatric team in the most favorable light. To address this issue, assessment of psychiatric symptoms for research purposes is recommended to occur independently from the required clinical evaluation, as the investigators will do in the proposed study. Nevertheless, studies focusing on the relationship between specific diagnoses and postoperative outcomes may fail to account for other psychological constructs that may be shared across diagnoses. Mood disorders, BED, and SUDs all share the common psychological construct of impulsivity, considered an important aspect of executive functioning. A lack of impulse control may contribute to the excessive weight gain seen in extreme obesity and may impact the results of bariatric surgery.

Disinhibition and Impulsivity among Persons with Extreme Obesity; Studies have suggested that individuals with obesity, and in particular those with extreme obesity presenting for bariatric surgery, show some deficits in executive functioning. For example, candidates for bariatric surgery have shown deficits in working memory, mental flexibility, motor speed and complex attention.These deficits could impact comprehension and retention of information presented to patients during the preoperative consultation process and, thus, negatively impact the ability to adhere to the dietary and behavioral changes required for an optimal postoperative outcome. At the same time, metabolic dysregulation, such as insulin resistance or hyperglycemeia seen in type 2 diabetes, also is associated with cognitive deficits, suggesting a potential physiological mechanism for the relationship. Dietary disinhibition, defined as a loss of control over eating, plays a central role in the overconsumption of food and, subsequently, the development of obesity. Disinhibition is similar to impulsivity, the term more commonly used in the substance use and smoking cessation literatures. Impulsivity is a multi-faceted construct and refers to the absence of the ability to inhibit an automatic behavior (otherwise known as response inhibition) and the tendency to discount future consequences in favor of more immediate outcomes (known as delay discounting). Similar to the role of disinhibition in obesity, impulsivity contributes to the development of and relapse with SUDs. Indeed, response inhibition and delay discounting are associated with both SUDs and obesity. Both also predict response to treatment for both SUDs and obesity. Chronic overeating and binge eating share several neurobiological and behavioral similarities with SUDs. In this regard, both may be viewed as behavioral disorders, in which intake (of food, alcohol, and/or drugs) escalates to a rate that is unhealthy and maladaptive. Nevertheless, the specific nature of the relationship between binge eating and substance use remains to be fully elucidated. There are similarities between binge eating and addictive disorders, including craving for the desired substance (drug or highly palatable food), a sense of loss of control when using, repeated attempts to control use despite clear adverse consequences, and the dedication of much time in obtaining and using the substance. Thus, the disinhibition observed with obesity and binge eating, the impulsivity seen with substance use disorders, and the emotional dysregulation associated with mood disorders all likely share commonalities that may both contribute to the development of extreme obesity and also may be associated with weight loss and changes in psychosocial status after bariatric surgery.

Psychosocial Status and Psychopathology after Bariatric Surgery:

In general, individuals who undergo bariatric surgery report dramatic improvements in psychosocial status and functioning postoperatively. The vast majority of patients report significant reductions in symptoms of depression and anxiety in the first postoperative year. They also report significant improvements in health and weight-related quality of life. Patients also report improvements in body image, sexual functioning, and relationship satisfaction. The relationship between preoperative psychopathology and postoperative outcomes is less robust. Livhits and colleagues reviewed this literature and concluded that the preoperative factors of BMI, BED, and the presence of personality disorders provided the strongest negative associations with postoperative weight loss. At least two studies have suggested that preoperative psychopathology, particularly mood and anxiety disorders, is associated with smaller weight postoperative weight losses. The relationship between BED and postoperative weight loss is unclear; some studies have found a relationship between preoperative BED and postoperative weight loss while others have not. Additionally, two studies have suggested that a history of substance abuse is associated with larger weight losses following bariatric surgery. The interpretation of this counterintuitive finding is that the self-regulation skills that help patients maintain their sobriety also help patients adhere to the demands of the recommended postoperative diet.