Epidemiological Study in FRONtoTemporal Dementia

Active, not recruiting

• Conditions: Frontotemporal Dementia

• Registration Number: NCT05075187
• Lead Sponsor: CENTOGENE GmbH Rostock

Brief Summary

An international, multicenter, epidemiological observational study aims to investigate the prevalence of genetic etiologies in patients diagnosed with FTD or clinically suspected for FTD.

Detailed Description

Frontotemporal dementia (FTD) is a genetically and pathologically heterogeneous neurodegenerative disease caused by the loss or damage of nerve cells in the brain's frontal and temporal lobes. This leads to abnormalities in behaviour, personality, and language comprehension problems. Also, people with FTD show movement disorders like tremor, rigidity, difficulty in coordination, muscle spasms and weakness. FTD's etiology is sporadic or heritable. Sixty to 70% of FTD cases are sporadic, while 30 to 40% are inherited (familial aggregation). For this study, blood samples were collected from clinically diagnosed or suspected FTD patients and were analysed for a broad range of pathogenic variants in genes associated with FTD. The scientific insights acquired from this study will help identify novel therapeutic targets and develop/ investigate potential disease-modifying drugs.

Study Timeline

• Study Start: 2021-09-01
• Study First Submitted: 2021-09-30
• Study First Submitted QC: 2021-09-30
• Study First Posted: 2021-10-12
• Status Verified: 2023-11
• Last Update Submitted: 2023-11-28
• Last Update Posted: 2023-11-29
• Primary Completion: 2024-06-30
• Study Completion: 2024-09-30

Recruitment & Eligibility

• Status: ACTIVE_NOT_RECRUITING
• Sex: All
• Target Recruitment: 4500

Inclusion Criteria

• Informed consent, which includes reference to the genetic testing, is obtained from the participant/legal guardian
• The participant is aged between 25 to 85 years
• The participant is diagnosed with Frontotemporal dementia (FTD) or has signs or symptoms of FTD

Exclusion Criteria

Not provided

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
To investigate the prevalence of genetic etiologies in FTD by genotyping FTD participants/ FTD suspected participants	15 months

Trial Locations

Locations (37)

AZ Damiaan; 🇧🇪 Oostende, West Flanders, Belgium

CHU de Liege; 🇧🇪 Liège, Belgium

Hanau Hospital; 🇩🇪 Hanau, Hessen, Germany

Gertrudis Klinik; 🇩🇪 Leun, Hessen, Germany

University Hospital Dresden; 🇩🇪 Dresden, Saxony, Germany

University Medical Center Hamburg Eppendorf; 🇩🇪 Hamburg, Schleswig-Holstein, Germany

University of Lübeck; 🇩🇪 Lübeck, Schleswig-Holstein, Germany

RWTH Aachen University; 🇩🇪 Aachen, Germany

Hochtaunus-Kliniken gGmbH; 🇩🇪 Bad Homburg, Germany

AGZ of Charite Universitätsmedizin Berlin; 🇩🇪 Berlin, Germany

Scroll for more (27 remaining)