Cognitive Impairement In Frontotemporal Dementia
Overview
- Phase
- N/A
- Intervention
- Not specified
- Conditions
- Frontotemporal Degeneration
- Sponsor
- University of Pennsylvania
- Enrollment
- 997
- Locations
- 1
- Primary Endpoint
- Progression
- Status
- Completed
- Last Updated
- 5 years ago
Overview
Brief Summary
This is an observational study that aims to better understand the genetic causes of frontotemporal degeneration (FTD), Multiple Systems Atrophy (MSA), and Progressive Supranuclear Palsy (PSP). It is hoped the information gathered in this study will help lead to better diagnostics and future treatments.
Detailed Description
Comparative and longitudinal studies reveal clinical differences between subgroups of patients with frontotemporal dementia (FTD), including Progressive Non-fluent Aphasia (PNFA), Semantic Dementia (SD), patients with a disorder of social comportment and personality (SOC), and non-aphasic patients with executive dysfunction (EXEC). MRI studies of cortical atrophy and fMRI studies show correlated neural defects in FTD subgroups. The investigators will obtain converging evidence from multiple sources to test hypotheses about the neural basis for cognitive functions such as semantic memory, grammatical processing, and social functioning in these FTD subgroups, while improving clinical care for these patients. Recent studies have linked progressive supra nuclear palsy (PSP) and multiple systems atrophy (MSA) to FTD. The investigators will obtain comparable neuropsychological and biomarker data in order to compare these patient groups.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Individuals who have been diagnosed with FTD, PSP, and MSA
Exclusion Criteria
- •Individuals under 18 years of age
- •People with pacemakers or certain metallic implants
- •pregnant women
Outcomes
Primary Outcomes
Progression
Time Frame: This is a natural history study - participants are followed from date of enrollment until death, withdrawl, or funding is no longer available, or until 984 months have passed
Changes over time in MRI and cognitive testing data.
Secondary Outcomes
- Impaired semantic memory in Semantic Dementia (SD).(This is a natural history study - participants are followed from date of enrollment until death, withdrawl, or funding is no longer available, or until 984 months have passed)