Cognitive Impairement In Frontotemporal Dementia

Completed

• Conditions: Frontotemporal Degeneration; Progressive Supranuclear Palsy; Multiple System Atrophy
• Interventions: Other: None-Observation Only

• Registration Number: NCT03452956
• Lead Sponsor: University of Pennsylvania

Brief Summary

This is an observational study that aims to better understand the genetic causes of frontotemporal degeneration (FTD), Multiple Systems Atrophy (MSA), and Progressive Supranuclear Palsy (PSP). It is hoped the information gathered in this study will help lead to better diagnostics and future treatments.

Detailed Description

Comparative and longitudinal studies reveal clinical differences between subgroups of patients with frontotemporal dementia (FTD), including Progressive Non-fluent Aphasia (PNFA), Semantic Dementia (SD), patients with a disorder of social comportment and personality (SOC), and non-aphasic patients with executive dysfunction (EXEC). MRI studies of cortical atrophy and fMRI studies show correlated neural defects in FTD subgroups. The investigators will obtain converging evidence from multiple sources to test hypotheses about the neural basis for cognitive functions such as semantic memory, grammatical processing, and social functioning in these FTD subgroups, while improving clinical care for these patients. Recent studies have linked progressive supra nuclear palsy (PSP) and multiple systems atrophy (MSA) to FTD. The investigators will obtain comparable neuropsychological and biomarker data in order to compare these patient groups.

Study Timeline

• Study Start: 2003-07-01
• Study First Submitted: 2018-02-26
• Study First Submitted QC: 2018-02-26
• Study First Posted: 2018-03-02
• Primary Completion: 2020-07-15
• Study Completion: 2020-07-15
• Status Verified: 2020-11
• Last Update Submitted: 2020-11-10
• Last Update Posted: 2020-11-12

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 997

Inclusion Criteria

• Individuals who have been diagnosed with FTD, PSP, and MSA

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Exclusion Criteria

• Individuals under 18 years of age
• People with pacemakers or certain metallic implants
• pregnant women

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Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
FTD Cohort	None-Observation Only	No intervention-observation only

Primary Outcome Measures

Name	Time	Method
Progression	This is a natural history study - participants are followed from date of enrollment until death, withdrawl, or funding is no longer available, or until 984 months have passed	Changes over time in MRI and cognitive testing data.

Secondary Outcome Measures

Name	Time	Method
Impaired semantic memory in Semantic Dementia (SD).	This is a natural history study - participants are followed from date of enrollment until death, withdrawl, or funding is no longer available, or until 984 months have passed	The impact of cortical atrophy on language processing.

Trial Locations

Locations (1)

University of Pennsylvania; 🇺🇸 Philadelphia, Pennsylvania, United States