Inspiratory Muscle Training in Heart Failure With Preserved Ejection Fraction

Mayo Clinic1 site in 1 country68 target enrollmentOctober 9, 2024

Overview

This study is being done to determine how inspiratory muscle training impacts inspiratory muscle function during exercise in heart failure patients.

Registry

clinicaltrials.gov

Start Date

October 9, 2024

End Date

April 1, 2028

Last Updated

6 months ago

Study Type

Interventional

Study Design

Parallel

Sex

All

Sponsor

Responsible Party

Principal Investigator

Joshua R. Smith

Principal Investigator

Mayo Clinic

•≥18 yrs of age
•Receiving SGLT2 inhibitors and spironolactone (and beta-blocker use for HFpEF patients with hypertension) for \>3 months
•NYHA symptoms I-III
•Body mass index ≤40 kg/m2
•Currently non-smokers with \<20 pack year history
•Able to exercise (i.e. without significant orthopedic limitations or musculoskeletal disorders limiting their ability to exercise)

•Sustained ventricular tachycardia and/or ventricular fibrillation within 21 days of visit 1
•Second or third degree heart block
•Body mass index \>40 kg/m2
•Current smokers and/or smoking history \>20 pack years
•Pregnant women (testing will be done by research team if requested)
•Glomerular filtration rate of \<30 mL/min/1.73m2 (initial screen via clinical record within the past 6 months and this will be assessed on Visit 1)
•Individuals who are not able to engage in exercise
•Uremia, history of allergy to iodides
•Peripheral artery disease
•Alanine transaminase and/or aspartate transaminase greater than 2 times the upper limit of normal (via clinical record within the past 6 months)