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临床试验/NCT01151267
NCT01151267已完成不适用

Hypercapnic Spontaneous Hyperpnoea and Recovery From Sevoflurane Anesthesia

University Health Network, Toronto2 个研究点 分布在 1 个国家目标入组 44 人开始时间: 2009年7月最近更新:
适应症

试验速览

阶段
不适用
状态
已完成
入组人数
44
试验地点
2
主要终点
Time from the end of anesthesia to the readiness for post-anesthesia care unit (PACU) discharge.

研究概览

简要总结

The rate of elimination of inhalation agent is directly proportional to the degree of alveolar ventilation. Using Isocapnic Hyperpnoea (IH) device, it is possible to maintain constant end-tidal CO2 with increased minute ventilation. This is achieved by passively adding a flow of CO2 to the inspirate in proportion to increases in ventilation above the baseline. In animal and human studies IH shortens the time of awakening from isoflurane and sevoflurane anesthesia when manual positive pressure ventilation is applied. IH device could be used for spontaneous hyperpnoea as well. The investigators want to compare recovery times from sevoflurane anesthesia in patients with application of hypercapnic spontaneous hyperpnoea (HSH) versus the standard anesthesia protocol (controls). 44 patients ill be randomized to either HSH facilitated recovery, or conventional recovery (controls).The time intervals from the end of anesthesia (turning off the vaporizer) until recovery milestones will be recorded.

研究设计

研究类型
Interventional
分配方式
Randomized
干预模型
Parallel
主要目的
Treatment
盲法
Single (Outcomes Assessor)

入排标准

年龄范围
18 Years 至 80 Years(Adult, Older Adult)
性别
Female
接受健康志愿者

入选标准

  • elective gynecological surgery
  • age 18-80
  • ASA I-III
  • informed consent

排除标准

  • ASA IV-V,
  • contra-indications to sevoflurane anesthesia or other anesthetics included in the protocol
  • history of cardiac or respiratory disease
  • intracranial pathology
  • alcohol or drug abuse
  • psychiatric illness and/or medications

结局指标

主要结局

Time from the end of anesthesia to the readiness for post-anesthesia care unit (PACU) discharge.

时间窗: End of anesthesia (turning off the vaporizer) until readiness for PACU discharge, approximately 30 minutes to 2 hours

次要结局

  • Comparison of pain and sedation scores(End of anesthesia (turning off the vaporizer) to PACU discharge, approximately 30 minutes to 2 hours)

研究者

申办方类型
Other
责任方
Sponsor

研究点 (2)

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