Hypercapnic Spontaneous Hyperpnoea and Recovery From Sevoflurane Anesthesia
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 44
- 试验地点
- 2
- 主要终点
- Time from the end of anesthesia to the readiness for post-anesthesia care unit (PACU) discharge.
研究概览
简要总结
The rate of elimination of inhalation agent is directly proportional to the degree of alveolar ventilation. Using Isocapnic Hyperpnoea (IH) device, it is possible to maintain constant end-tidal CO2 with increased minute ventilation. This is achieved by passively adding a flow of CO2 to the inspirate in proportion to increases in ventilation above the baseline. In animal and human studies IH shortens the time of awakening from isoflurane and sevoflurane anesthesia when manual positive pressure ventilation is applied. IH device could be used for spontaneous hyperpnoea as well. The investigators want to compare recovery times from sevoflurane anesthesia in patients with application of hypercapnic spontaneous hyperpnoea (HSH) versus the standard anesthesia protocol (controls). 44 patients ill be randomized to either HSH facilitated recovery, or conventional recovery (controls).The time intervals from the end of anesthesia (turning off the vaporizer) until recovery milestones will be recorded.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single (Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 80 Years(Adult, Older Adult)
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •elective gynecological surgery
- •age 18-80
- •ASA I-III
- •informed consent
排除标准
- •ASA IV-V,
- •contra-indications to sevoflurane anesthesia or other anesthetics included in the protocol
- •history of cardiac or respiratory disease
- •intracranial pathology
- •alcohol or drug abuse
- •psychiatric illness and/or medications
结局指标
主要结局
Time from the end of anesthesia to the readiness for post-anesthesia care unit (PACU) discharge.
时间窗: End of anesthesia (turning off the vaporizer) until readiness for PACU discharge, approximately 30 minutes to 2 hours
次要结局
- Comparison of pain and sedation scores(End of anesthesia (turning off the vaporizer) to PACU discharge, approximately 30 minutes to 2 hours)
