topical tranexamic acid in perioperative blood loss of the posterior lumbar spinal surgery
Phase 3
Recruiting
- Conditions
- Condition 1: ???? ???? ???. Condition 2: ?????? ???? ??? ???? ???? ?????.Other intervertebral disc displacement, lumbar regionUnspecified fracture of unspecified lumbar vertebra, initial encounter for closed fractureM51.26S32.009A
- Registration Number
- IRCT20200203046351N1
- Lead Sponsor
- Bagheiat-allah University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 104
Inclusion Criteria
Patients with age between 18 to 75 years .
Patients whom needs posterior lumbar spinal surgery
Traumatic patients ( in the first 3 weeks after injury)
Non-traumatic patients (with maximum 4 spinal level envolved)
Exclusion Criteria
History of thromboembolism
Emergent surgery with indications other than neurosurgical indications
Treatment with other drugs that affect blood coagulation such as sodium valproate
Any transexamic acid intake before (eg polymenorrhea in women or in dentistry)
Treatment with anticoagulants
Treatment with antiplatelets
Spinal penetrating injury
Hemodynamical unstability
History of epilepsy or seizure
Liver malfunction
Renal failure
Abnormal results of laboratory coagulation tests
Patient's reluctance
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Intraoperative blood loss. Timepoint: At the end of the operation. Method of measurement: with use of standard anesthesia chart by ml.
- Secondary Outcome Measures
Name Time Method Duration of hospitalization. Timepoint: Time of discharge. Method of measurement: Questionnaire.;Coagulation studies. Timepoint: At the beginning of the study and post op. Method of measurement: questionnaire.;Duration of returning to work. Timepoint: 2 month post op. Method of measurement: questionnaire.