Effects of Capsaicin on Salty Gustatory Cortices in Human
试验速览
- 阶段
- 4 期
- 状态
- 已完成
- 发起方
- 入组人数
- 80
- 试验地点
- 1
- 主要终点
- Neuroimaging changes of salty gustatory cortices
研究概览
简要总结
Excess dietary salt intake is closely associated with the development of hypertension and cardiocerebral vascular diseases. Preference of high salt diet might involve salty gustatory cortices change. This study focuses on examining the neuroimaging changes of salty gustatory cortices under different concentration of NaCl solution with or without capsaicin intervention through brain PET/CT scan.
详细描述
Hypertension and its related complications are common health problems that can lead to multiple organ damage and death. Excessive salt intake plays an important role in the development of hypertension.
The experimental design is a randomized, double-blind, interventional study to investigate the neuroimaging changes of salty gustatory cortices under different concentration of NaCl solution with or without capsaicin intervention through brain PET/CT scan.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- Triple (Participant, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Age ≥ 18 years and ≤ 65 years.
- •Willing and able to provide written informed consent.
- •Willing and able to comply with all study procedures.
排除标准
- •High basic metabolic rate, tumor, epilepsia.
- •Hypogeusia or loss due to neural system disease or oral and digestive disease.
- •Capsaicin allergy and poor compliance.
- •Recently oral diuretics and participate in other pharmacological experiment in 3 months.
- •Acute infection, cancer, serious arrhythmias, drug or alcohol abuse.
- •Currently have cold, fever, acidosis, dehydration, diarrhea, vomiting during the study.
- •Unwilling or unable to communication due to the dysnoesia and language disorders.
- •Severe neural or psychiatric diseases that would preclude fully understand and corporation in the study.
- •History of allergic reaction attributed to 18F-FDG.
- •Pregnancy or lactation.
结局指标
主要结局
Neuroimaging changes of salty gustatory cortices
时间窗: 45min
Buccal administration of test solution for five mins, and PET/CT scan after 40 mins
次要结局
未报告次要终点
研究者
Zhiming Zhu
Director of the Dept. of Hypertension & Endocrinology
Third Military Medical University