Assessment of the Force Frequency Relationship of the Myocardium After On-pump CABG Surgery
Not Applicable
- Conditions
- Adult Cardiac Surgery
- Interventions
- Device: External Pacing Box
- Registration Number
- NCT02407574
- Lead Sponsor
- University of Liege
- Brief Summary
The aim of the study is to determine whether increasing the heart rate by epicardial atrial pacing after surgery improves the contractile force of the myocardium. After complete weaning from CPB, several pressure-loops of the LV will be recorded at different levels of preload using transoesophageal echo, invasive blood pressure monitoring. The preload will be manipulated by adding fluid from the CPB reservoir or draining fluid into the CPB reservoir.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 20
Inclusion Criteria
- CABG only surgery
- Preopeartive LVEF ≥ 53 %
- Use of epicardial pacing wires to assist CPB weaning
Exclusion Criteria
- Contra-indication to TEE
- AV block at the time of CPB weaning
- Sinus rhythm less than 50 or more than 90 BPM after CPB weaning.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- CROSSOVER
- Arm && Interventions
Group Intervention Description Atrial pacing first External Pacing Box Stepwise preload increase by repeated administration of 100 mL of fluid during atrial pacing and then stepwise preload reduction by repeated drainage of 100 mL of fluid during spontaneous rhythm. Spontaneous rhythm first External Pacing Box Stepwise preload increase by repeated administration of 100 mL of fluid during spontaneous rhythm and then stepwise preload reduction by repeated drainage of 100 mL of fluid during atrial pacing.
- Primary Outcome Measures
Name Time Method End-systolic elastane of the left ventricle. 30 minutes after CPB weaning
- Secondary Outcome Measures
Name Time Method