Vasodilator Free Measure of Fractional Flow Reserve
Completed
- Conditions
- Coronary Stenosis
- Registration Number
- NCT01118481
- Lead Sponsor
- Imperial College London
- Brief Summary
Narrowing of coronary arteries interferes with blood flow and can cause chest pain. Cardiologists sometimes quantify the extent of the narrowing by measuring the fractional flow reserve (the ratio of the pressure in the aorta to the pressure downstream of the narrowing under conditions of maximal flow). We propose a new technique based on principles of wave intensity analysis (WIA) to better assess coronary stenosis and the significance of the narrowing without the need for administration of vasodilator agents such as adenosine. This would simplify assessment and improve our ability to advise patients whether stent treatment will help their symptoms.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 157
Inclusion Criteria
- Patients with coronary stenosis
Exclusion Criteria
- Patient's with cardiac pacemakers, valvular heart disease, and chronic renal failure
- Unable to consent
- Contraindications to adenosine
- Contraindications to cardiac MRI
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Correlation and descriptive characteristics between adenosine free measure of stenosis severity and FFR Study end
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Imperial College NHS Trust
🇬🇧London, United Kingdom