JPRN-jRCTs032180344
Recruiting
未知
Short-term effect of positive airway pressure therapy in patients with atrial fibrillation (AF) and sleep-disordered breathing (SDB) - SYNERGY-AF
Kasai Takatoshi0 sites64 target enrollmentMarch 18, 2019
Overview
- Phase
- 未知
- Intervention
- Not specified
- Conditions
- Not specified
- Sponsor
- Kasai Takatoshi
- Enrollment
- 64
- Status
- Recruiting
- Last Updated
- 2 years ago
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •1\)Adults (age of 20 or greater)
- •2\)Patients with AF (paroxysmal, persistent, and permanent)
- •3\)Moderate to severe SDB (i.e. AHI15\-39 by home polygraphy test)
- •4\) plasma BNP \>40pg/mL or NT\-proBNP \>125pg/m
Exclusion Criteria
- •1\)LV systolic dysfunction (LV ejection fraction less than or equal to 45% on echocardiogram)
- •2\)Severe organic valvular diseases
- •3\)Acute coronary syndrome within 3 months
- •4\)Patients who underwent or planned for following treatments within 3 months from randomization: pacemaker; implantable cardiac defibrillator (ICD); cardiac resynchronization therapy (CRT); cardiac surgery; percutaneous coronary intervention (PCI); transcatheter aortic valve intervention (TAVI)
- •5\)Life\-threatening diseases (uncured malignancy, severe chronic pulmonary diseases with oxygen inhalation or specific medication, and end stage renal disease with dialysis)
- •6\)Patients who received for PAP therapy within 2 weeks
- •7\)Epworth sleepiness scale(ESS) greater than or equal to 11 or occupational driver
- •8\)Pregnancy
- •9\)Symptomatic OSA patients with class1 indication for PAP therapy in guidelines for diagnosis and treatment of acute and chronic heart failure (JCS 2017/JHFS 2017\)
- •10\)Patients eligible for CPAP initiation with reimbursement (AHI greater than or equal to 40\)
Outcomes
Primary Outcomes
Not specified
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