Blood-brain barrier in cerebral small vessel disease.
- Conditions
- Blood-brain barrier, cerebral small vessel disease, lacunar stroke, cognitive impairment, DCE-MRI
- Registration Number
- NL-OMON26559
- Lead Sponsor
- Maastricht University Medical Center
- Brief Summary
/A
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- Not specified
- Target Recruitment
- 120
Inclusion Criteria
Patients with lacunar stroke, patients with mild vascular cognitive impairment (VCI), and healthy subjects will be included.
Exclusion Criteria
Exclusion criteria for all subjects:
1. Age <18 year;
Study & Design
- Study Type
- Observational non invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method 1. Quantified BBB permeability in cSVD patients and healthy controls;<br /><br>2. Cognitive function, related to BBB permeability, at baseline and at follow-up.
- Secondary Outcome Measures
Name Time Method Structural brain lesions on MRI, related to BBB permeability, at baseline and at follow-up.