Dexmedetomidine Sedation and Cardiopulmonary Bypass
- Conditions
- Coronary Artery Bypass Grafting
- Interventions
- Registration Number
- NCT02727621
- Lead Sponsor
- Assiut University
- Brief Summary
Dexmedetomidine is a unique sedative anesthetic agent that allows accurate control of the depth of sedation and provides analgesia, cardio protection, renal protection, and neuroprotection without causing respiratory depression. It is an alpha 2-adrenoreceptor agonist that modulates the release of catecholamines from the central and autonomic nervous systems. When patients sedated by dexmedetomidine are allowed to become responsive, they are calm and cooperative (1). No other sedative agent has this feature, and sedated patients frequently awaken in a confused state. Investigators are conducting this study project to compare between dexmedetomidine based and propofol based anesthetic techniques with regard to hemodynamic changes, stress hormone release as well as cytokines in patients undergoing CPB for coronary revascularization.
- Detailed Description
100 patients undergoing elective CPB for coronary revascularization surgery. On the morning of operation the patients were randomized to receive one of two anesthetic techniques dependent on the type of sedation used. Standard anesthetic technique will be used for all patients except for using dexmedetomidine sedation in one group and propofol sedation in the other group.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 100
- patients scheduled for elective coronary revascularization surgery with cardiopulmonary bypass
- Severely impaired left ventricular function (ejection fraction <40%)
- Valvular heart disease
- Low cardiac output syndrome
- Uncontrolled rapid atrial fibrillation
- On plavix less than one week
- Severe systemic non-cardiac disease
- Infectious disease
- Poorly controlled diabetes mellitus
- patients on corticosteroids or other immunosuppressive treatment
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Propofol group propofol - Dexmedetomidine group Dexmedetomidine -
- Primary Outcome Measures
Name Time Method cardiac index within intraoperative period cardiac index measured in L/min/m2
- Secondary Outcome Measures
Name Time Method inotrope score 1st 24 hours appropriate score
sedation score 1st 24 hours appropriate score
heart rate within intraoperative period heart rate measured in beat/min.
pulmonary capillary wedge pressure within intraoperative period pulmonary capillary wedge pressure measured in mm.Hg
duration of mechanical ventilation 1st week duration of mechanical ventilation measured in hours
mean pulmonary artery pressure within intraoperative period mean pulmonary artery pressure measure in mm.Hg
cardiac output within intraoperative period cardiac output measured in L/min
mean arterial blood pressure within intraoperative period mean arterial blood pressure measured in mm.Hg
central venous pressure within intraoperative period central venous pressure measured in mm.Hg
systemic vascular resistance index within intraoperative period systemic vascular resistance index measured in dyn.sec/cm5/m2
pulmonary vascular resistance index within intraoperative period pulmonary vascular resistance index measured in dyn.sec/cm5/m2
stroke volume index within intraoperative period stroke volume index measured in ml/m2/beat
left ventricular stroke work index within intraoperative period left ventricular stroke work index measured in gm/m2/beat
Trial Locations
- Locations (1)
Faculty of Medicine
🇪🇬Assiut, Egypt