NL-OMON55346撤回不适用
Dopamine synthesis capacity in patients with borderline personality disorder and auditory verbal hallucinations - DOPA PET in BPD with AVH
适应症
试验速览
- 阶段
- 不适用
- 状态
- 撤回
- 入组人数
- 63
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 18 至 64（—）
入选标准
- •BPD patients
- •Patients can participate within the BPD group if they fulfil the following
- •criteria: 1. BPD with the aid of the Structured Clinical Interview for DSM-5
- •Personality Disorders, 2. Age 18 to 60 years, 3. Persistent AVH in a frequency
- •of at least weekly for a duration of 6 months, 4. Female patients are not
- •pregnant. 5. Patients did not participate in a scientific research study during
- •the last six months involving radiation (or any other form of exposure to the
- •same amount of radiation within the past year via e.g., transatlantic flights),
- •6. Have no magnetic resonance imaging (MRI)-incompatible implants in the body
- •(such as an insulin-pump, pace-maker, or non-removable piercings). 7. Have no
- •metal particles in their eyes. 8. Have no tattoo*s containing red pigments
- •which could form a safety risk during the MRI-scan, 9. No schizophrenia or
- •schizoaffective disorder 10. No use of methylphenidate or dexamphetamine,
- •haloperidol or valproic acid, carbidopa, glucagon and reserpine, 11. Being able
- •to answer questions, 12. No claustrophobia, 13. Mentally competent.
- •If the diagnoses have been made longer than 4 years prior to inclusion, the
- •SCID 5 and MINI Plus will be used again to confirm the criteria for inclusion.
- •Schizophrenia group:
- •Patients can participate within the schizophrenia group if they fulfil the
- •following criteria: 1. Schizophrenia or schizoaffective disorder, diagnosed
- •with the Mini International Neuropsychiatric Interview Plus, 2. Age 18 to 60
- •years, 3. Persistent AVH in a frequency of at least weekly for a duration of 6
- •months, 4. Female patients are not pregnant. 5. Patient did not participate in
- •a scientific research study during the past year involving radiation (or any
- •other form of exposure to the same amount of radiation within the last six
- •months via e.g., transatlantic flights), 6. Have no MRI-incompatible implants
- •in the body (such as an insulin-pump, pace-maker, or non-removable piercings).
- •7. Have no metal particles in their eyes. 8. Have no tattoo*s containing red
- •pigments which could form a safety risk during the MRI-scan, 9. No BPD, and
- •10. No use of methylphenidate or dexamphetamine, haloperidol or valproic acid,
- •carbidopa, glucagon and reserpine, 11. Being able to answer questions 12. No
- •claustrophobia, 13. Mentally competent.
- •Patients do not need to be antipsychotic free as antipsychotics do not affect
- •dopamine synthesis (Jauhar et al., 2019).
- •Healthy controls
- •Participants were included in the group of healthy controls if they fulfil the
- •following criteria: 1. No DSM 5 diagnosis of current or past psychiatric
- •disorder or substance dependence other than nicotine dependence, investigated
- •with the SCID-5-PD and MINI Plus, 2. Age 18 to 60 years, 3. No AVH in the last
- •year prior to this study, 4. Female patients are not pregnant. 5. Patient did
- •not participate in a scientific research study during the last six months
- •involving radiation (or any other form of exposure to the same amount of
- •radiation within the past year via e.g., transatlantic flights), 6. Have no
- •MRI-incompatible implants in the body (such as an insulin-pump, pace-maker, or
- •non-removable piercings). 7. Have no metal particles in their eyes. 8. Have no
- •tattoo*s containing red pigments which could form a safety risk during the
- •MRI-scan and 9. No psyc
排除标准
- •see inclusion criteria
研究者
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