HCC Staging Modified by Tumor Micronecrosis
Completed
- Conditions
- Hepatocellular Carcinoma
- Interventions
- Behavioral: tumor micronecrosis
- Registration Number
- NCT05739110
- Lead Sponsor
- Zhejiang University
- Brief Summary
Tumor micronecrosis is a pathological feature that reflects malignant biological behavior in hepatocellular carcinoma (HCC). This study aimed to evaluate the prognostic significance of tumor micronecrosis based on the current BCLC and TNM staging systems, and futher improve the performance of the staging models by establishing modified new staging models including tumor micronecrosis.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 1100
Inclusion Criteria
- primary and histologically confirmed HCCs
- patients who underwent curative liver resection
Exclusion Criteria
- simultaneous presence of other tumors
- patients who had received preoperative antitumor therapies
- no available surgical specimens for evaluating micronecrosis status
- gross tumor necrosis and Nscore = 3
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description micronecrosis(+) group tumor micronecrosis Hepatocellular patients with tumor micronecrosis.
- Primary Outcome Measures
Name Time Method Overall survival from date after liver resection until death or last follow-up, whichever came first, assessed up to 72 months the number of months from the date of surgery to the date of the last follow-up visit or time of death.
- Secondary Outcome Measures
Name Time Method Disease-free survival from date after liver resection until recurrence or last follow-up, whichever came first, assessed up to 72 months the number of months from the date of surgery to the date of first confirmable recurrence or death
Trial Locations
- Locations (1)
the First Affiliated Hospital, School of Medicine, Zhejiang University
🇨🇳Hangzhou, Zhejiang, China