Differences in Sitting Versus Standing on Metabolic and Cardiovascular Measurements

• Conditions: Overweight and Obesity
• Interventions: Behavioral: sit/stand

• Registration Number: NCT03927638
• Lead Sponsor: Montclair State University

Brief Summary

This investigations examined the effect that posture has on metabolic and cardiovascular measurements. Further, it will explore the potential for body weight status or physical activity to influence these relationships. All subjects will complete a seated condition and a standing condition in a counterbalanced manner.

Detailed Description

The purpose of the present study was to evaluate both metabolic and cardiovascular responses to acute bouts of computer work while sitting and standing. Cardiovascular measurements were made using continuous non-invasive blood pressure monitoring and metabolic measurements were made using indirect calorimetry. Subjects will be grouped and analyzed based upon the weight status of the subject. All subjects will complete a seated condition and a standing condition in a counterbalanced manner. Investigators hypothesize that metabolic and cardiovascular responses will be elevated in the standing condition compared to sitting.

Study Timeline

• Study Start: 2018-11-11
• Study First Submitted: 2019-04-22
• Study First Submitted QC: 2019-04-24
• Study First Posted: 2019-04-25
• Status Verified: 2024-10
• Last Update Submitted: 2025-01-29
• Last Update Posted: 2025-01-31
• Primary Completion: 2028-05-15
• Study Completion: 2028-05-15

Recruitment & Eligibility

• Status: ENROLLING_BY_INVITATION
• Sex: All
• Target Recruitment: 80

Inclusion Criteria

• healthy adult

Exclusion Criteria

• Have a history of cancer, cardiac issues, hypertension, pulmonary disease, stroke, neurological or muscular dystrophy, uncontrolled diabetes, or any life threatening chronic conditions.
• Are currently being treated for infectious mononucleosis, hepatitis, pneumonia, or other infectious diseases.
• Are unable or unwilling to stand in one position continuously for 15-20 minutes at a time.
• Use nicotine products, or non-contraceptive hormonal therapy (birth control is okay).
• Are pregnant or trying to become pregnant.
• Are not between 18 and 50 years of age.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Normal Weight	sit/stand	Group is determined based upon subjects weight status. Subjects will preform computer work in the seated and standing position in a counterbalanced manner while metabolic and cardiovascular measurements are made.
Overweight/Obese	sit/stand	Group is determined based upon subjects weight status. Subjects will preform computer work in the seated and standing position in a counterbalanced manner while metabolic and cardiovascular measurements are made.

Primary Outcome Measures

Name	Time	Method
Carbon Dioxide Production	Approximately 15 minutes in each condition (sitting and standing)	Carbon Dioxide will be measured using indirect calorimetry.
Respiratory Exchange Ration (RER)	Approximately 15 minutes in each condition (sitting and standing)	RER will be calculated using oxygen and carbon dioxide value measure from indirect calorimetry.
Systolic Blood Pressure (SBP)	Approximately 15 minutes in each condition (sitting and standing)	Using human non-invasive blood pressure continuous monitoring placed on the middle finger of the non-dominant hand will be used to measure SBP based upon beat-by-beat finger pressure.
Oxygen Consumption	Approximately 15 minutes in each condition (sitting and standing)	Oxygen consumption will be measured using indirect calorimetry.
Diastolic Blood Pressure (DBP)	Approximately 15 minutes in each condition (sitting and standing)	Using human non-invasive blood pressure continuous monitoring placed on the middle finger of the non-dominant hand will be used to measure DBP based upon beat-by-beat finger pressure.
Ventilation	Approximately 15 minutes in each condition (sitting and standing)	Ventilation will be measured using indirect calorimetry.
Heart Rate	Approximately 15 minutes in each condition (sitting and standing)	Using human non-invasive blood pressure continuous monitoring placed on the middle finger of the non-dominant hand will be used to measure heart rate based upon beat-by-beat finger pressure.

Secondary Outcome Measures

Name	Time	Method
Weight	1 minute	Standard scale will be used to measure weight in kilograms.
Body Composition	Approximately 15 minutes	Body composition will be measured using air displacement plethysmography.
Total Peripheral Resistance (TPR)	Approximately 15 minutes in each condition (sitting and standing)	Using human non-invasive blood pressure continuous monitoring placed on the middle finger of the non-dominant hand will be uses to estimate TPR based upon beat-by-beat finger pressure.
Body Mass Index (BMI)	1 minute	Height in meters and weight in kilograms will be used to calculate BMI using the formula BMI = kg/m\^2.
Height	1 minute	Standard stadiometer will be used to measure height in meters.
Stroke Volume	Approximately 15 minutes in each condition (sitting and standing)	Using human non-invasive blood pressure continuous monitoring placed on the middle finger of the non-dominant hand will be used to estimate TPR based upon beat-by-beat finger pressure.
Cardiac Output (Q)	Approximately 15 minutes in each condition (sitting and standing)	Using human non-invasive blood pressure continuous monitoring placed on the middle finger of the non-dominant hand will be used to estimate Q based upon beat-by-beat finger pressure.
Muscle Oxygen Saturation	Approximately 15 minutes in each condition (sitting and standing)	Using Near-inferred spectroscopy muscle oxygen consumption will be monitored.

Trial Locations

Locations (1)

Montclair State University; 🇺🇸 Montclair, New Jersey, United States