Advanced Analysis of the Carotid Phonoangiography and Diseases
试验速览
- 阶段
- 不适用
- 入组人数
- 300
- 试验地点
- 1
- 主要终点
- progression of stenosis
研究概览
简要总结
Purpose: To investigate the different sound spectrum of carotid arteries and to analyze its relationship to the vessel disease, and to build a new biomarker about vascular disorder.
Methods: To record the carotid phonoangiography with digital stereoscopy and analysis the spectrum with different algorithm such as FFT, wavelet, entropy, complexity, and HHT. The results will be correlated and comparison to the finding in clinical, carotid Doppler and duplex, CTA, MR, and catheter angiography.
Statistics:
The significance of difference between parameters was computed using t-tests or paired t-test etc. A p value <0.05 is defined as significant.
详细描述
The investigators plan to recruit data from patients that come to their department for angiography study and intervention (n=300) with different disease entity such as atherosclerosis, tumor, aneurysm, arteriovenous malformation or fistula, and other vascular disorders. A period of about 20 seconds of the carotid phonoangiography was recorded.
Standard for comparison: catheter angiography, CTA, MRI/MRA. The degree of stenosis, the wall thickness, SI and density change was clustered and compared. The clinical and laboratory data will be reviewed and the vascular risk factors will be calculated.
Spectrum analysis: The sound spectrum will be analysis with the FFT, wavelet, entropy, complexity, and HHT algorithms.
The correlation between change of spectrums and also the correlated clinical, images, and laboratory change will be further analysis by statistic method.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 20 Years 至 90 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age: 20 years old to 99 years old
- •Gender: Unlimited
- •Because different types of brain diseases, those who received conventional catheter vascular examination.
排除标准
- •Neck inflammation locally who can not admit the sound.
- •Due to inability to cooperate to accept those recordings.
结局指标
主要结局
progression of stenosis
时间窗: three years
Follow-up the severity of the carotid stenosis and correlate its wall change
次要结局
- wall change(three years)
研究者
National Taiwan University Hospital
Chairman
National Taiwan University Hospital