A Comparison of levels of inflammatory markers in Gum Fluid levels during tooth Straightening: Aligners vs. Braces Study
Phase 4
- Conditions
- Health Condition 1: K088- Other specified disorders of teethand supporting structures
- Registration Number
- CTRI/2024/04/066214
- Lead Sponsor
- Dr Taanvi Miglani
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
Bimaxillary protrusion cases that require extraction of all 1st premolars for orthodontic correction.
No history of antibiotics and anti-inflammatory drugs in past 6 months preceding the study.
Periodontally healthy, with generalised probing depth less than or equal to 3 mm.
Exclusion Criteria
Presence of gingivitis and periodontitis
Presence of Systemic disease
Presence of bone disease
History of previous orthodontic treatment
Smoking habit
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Difference in the levels of biomarkers will be assessed.Timepoint: T0- GCF collected at beginning of treatment <br/ ><br>T1 - GCF collected 24 hours after intervention. <br/ ><br>T2- GCF collected after 21 days of intervention <br/ ><br>T4 – GCF collected after 6 months of intervention <br/ ><br>
- Secondary Outcome Measures
Name Time Method Assessment of RANKL/OPG ratio.Timepoint: T0- GCF collected at beginning of treatment <br/ ><br>T1 - GCF collected 24 hours after intervention. <br/ ><br>T2- GCF collected after 21 days of intervention <br/ ><br>T4 – GCF collected after 6 months of intervention <br/ ><br>