Characterization of neural networks underlying motor tic formation and suppressio

• Conditions: F95.1; F95.2; Chronic motor or vocal tic disorder; Combined vocal and multiple motor tic disorder [de la Tourette]

• Registration Number: DRKS00024834
• Lead Sponsor: Klinik für Psychiatrie und Psychotherapie, Klinikum der Universität zu Köln

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2021-04-21
• Study Completion: 2023-06-30
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Complete
• Sex: All
• Target Recruitment: 61

Inclusion Criteria

Fluent in the German language
- Age 18 to 65 years
- For Patients: Chronic motor tic disorder (F95.1) or chronic motor and vocal tic disorder (F95.2) as main diagnosis according to the International Classification of Diseases 10 (ICD 10)

Exclusion Criteria

- Active suicidal or homicidal ideation within last 6 months
- Current psychotic symptomatology
- Active or recent substance abuse (except intake of cannabis-based substances, if consumed for treatment of tics and if they are paused 72 hours before the experiment)
- Serious systemic medical disease that requires treatment
- Clinically relevant neurological disorder of the central nervous system such as stroke, epilepsy, neoplasia
- Mental retardation or other unstable psychiatric disorder that requires treatment
- Active medication with benzodiazepine that cannot be paused for 72 hours
- Withdrawal of consent

Study & Design

• Study Type: observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
1) Modulation in the theta (4-8 Hz) and beta (15-30 Hz) frequency band will be investigated in cortical areas (DLPFC, ACC, PCC) for the effect of voluntary tic suppression.

Secondary Outcome Measures

Name	Time	Method
1) Modulation in the theta (4-8 Hz) and beta (15-30 Hz) frequency bands will be examined in cortical areas (SMA, M1, Insula) for a relationship with urge sensation.<br>2) Differences in theta (4-8 Hz) and beta (15-30 Hz) frequency bands will be shown between blinks and blink tics primarily in areas of sensorimotor integration (SMA, insula).<br>3) Modulation of EEG signal during motor prediction task between patients and healthy controls will be expect in ACC.