CARDIOPROTECTIVE-NEPHROPROTECTIVE EFFECTS OF SEVOFLURANE IN COMPARISON WITH PROPOFOL IN DOUBLE VALVE SURGERY. USE OF SEVOFLURANE AS A PILLAR OF PROTECTION IN EXTRACORPOREAL CIRCULATION AND POSTOPERATIVE SEDATION
试验速览
- 阶段
- 3 期
- 状态
- 招募中
- 入组人数
- 70
- 试验地点
- 1
- 主要终点
- Evaluation variables: Sex, age, Cardiac index, creatinine, N-GAL, Stroke Volume index, heart rate, beats / min, mean arterial pressure, right ventricular end-diastolic pressure, Troponin I, NT-ProBNP, pre/postconditioning enzymes, renal dysfunction, inotropic support, days of ICU stay and circRNA values
研究概览
简要总结
To evaluate the effects of sevoflurane administration intra- (including the period of extracorporeal circulation ischemia) and postoperatively in patients undergoing double valve surgery with respect to propofol in terms of reducing myocardial damage and injury. For this, the levels of NT-ProBNP and troponin I will be measured; and its impact on myocardial preservation, through the measurement of the cardiac index intraoperatively and immediately postoperatively, as well as the use of inotropes for low cardiac output syndrome.
入排标准
- 年龄范围
- 18 years 至 65+ years（18-64 Years, 65+ Years）
- 接受健康志愿者
- 否
入选标准
- •Age ≥ 18 years.
- •Elective surgery cardiac surgery with double valve pump.
- •Use of Nido cardioplegia, common in this type of patient
排除标准
- •History of adverse reaction to sevoflurane or propofol.
- •Severe disease of any organ (lung, liver, kidney), diagnosed preoperatively.
- •Combined surgery (e.g. coronary or carotid surgery).
- •Patients in a situation of hemodynamic instability.
- •Heart failure or need to use inotropic or vasoactive drugs prior to the intervention.
- •Treatment with oral antidiabetics not suspended at least 48 hours before.
- •Treatment with euphylline/theophylline prior to the intervention.
- •Inability to grant informed consent.
- •Pregnancy or breastfeeding.
结局指标
主要结局
Evaluation variables: Sex, age, Cardiac index, creatinine, N-GAL, Stroke Volume index, heart rate, beats / min, mean arterial pressure, right ventricular end-diastolic pressure, Troponin I, NT-ProBNP, pre/postconditioning enzymes, renal dysfunction, inotropic support, days of ICU stay and circRNA values
Evaluation variables: Sex, age, Cardiac index, creatinine, N-GAL, Stroke Volume index, heart rate, beats / min, mean arterial pressure, right ventricular end-diastolic pressure, Troponin I, NT-ProBNP, pre/postconditioning enzymes, renal dysfunction, inotropic support, days of ICU stay and circRNA values
次要结局
未报告次要终点
研究者
Elvira Bonilla
Scientific
Fundacion Publica Andaluza Para La Investigacion De Malaga En Biomedicina Y Salud