An fMRI Study of the Effects of Clavulanic Acid on Drug Addiction
- Conditions
- Tobacco Use Disorder
- Interventions
- Drug: Placebo oral capsule
- Registration Number
- NCT03713424
- Lead Sponsor
- University of Missouri-Columbia
- Brief Summary
This research study is looking into the effects of clavulanic on smoking behavior in adult cigarette smokers. The primary study hypothesis is that, compared to placebo, clavulanic acid will reduce smoking over the course of the study.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- RECRUITING
- Sex
- All
- Target Recruitment
- 30
Not provided
Not provided
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Placebo Placebo oral capsule 4-day, twice-daily oral capsule administration Clav Clavulanic Acid 4-day 125 bid oral capsule administration
- Primary Outcome Measures
Name Time Method Cigarette Smoking 5 days Biochemical smoking assessment (breath carbon monoxide) at each study visit.
Self Reported Side Effects 5 Days Number of reported side effects
- Secondary Outcome Measures
Name Time Method Magnitude of change in BOLD fMRI brain response to smoking related images 4 days Measure the effects of Clavulanic Acid on fMRI BOLD response to images (change from baseline to end of study) while participants undergo functional magnetic resonance imaging
Magnitude of change in resting-stated fMRI brain connectivity 4 days Measure the effects of Clavulanic Acid on resting-state functional connectivity (change from baseline to end of study) while participants undergo functional magnetic resonance imaging.
Trial Locations
- Locations (1)
University of Missouri - Columbia
🇺🇸Columbia, Missouri, United States