NCT03713424招募中2 期
An fMRI Study of the Effects of Clavulanic Acid on Drug Addiction
适应症
干预措施
相关药物
试验速览
- 阶段
- 2 期
- 状态
- 招募中
- 入组人数
- 30
- 试验地点
- 1
- 主要终点
- Cigarette Smoking
研究概览
简要总结
This research study is looking into the effects of clavulanic on smoking behavior in adult cigarette smokers. The primary study hypothesis is that, compared to placebo, clavulanic acid will reduce smoking over the course of the study.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- Double (Participant, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- 未提供
排除标准
- 未提供
研究组 & 干预措施
Clav
Active Comparator
4-day 125 bid oral capsule administration
干预措施: Clavulanic Acid (Drug)
Placebo
Placebo Comparator
4-day, twice-daily oral capsule administration
干预措施: Placebo oral capsule (Drug)
结局指标
主要结局
Cigarette Smoking
时间窗: 5 days
Biochemical smoking assessment (breath carbon monoxide) at each study visit.
Self Reported Side Effects
时间窗: 5 Days
Number of reported side effects
次要结局
- Magnitude of change in BOLD fMRI brain response to smoking related images(4 days)
- Magnitude of change in resting-stated fMRI brain connectivity(4 days)
研究者
Brett Froeliger
Professor
University of Missouri-Columbia
研究点 (1)
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