Interest of the Injection of Morphine, in Addition to a Local Anesthetic When Performing a Combined Spinal-epidural for Labor Analgesia
试验速览
- 阶段
- 3 期
- 状态
- 已完成
- 发起方
- CHU de Reims
- 入组人数
- 144
- 试验地点
- 2
- 主要终点
- Visual analog pain scale
研究概览
简要总结
The addition of morphine to a local anesthetic when performing an epidural analgesia during labor analgesia has improved the efficiency and the action duration of analgesia. One limitation of this technique is the time of installation of the analgesic effect (about 30 minutes) when using the only epidural. Therefore, the technique of sequential combined spinal epidural was introduced. This is to shorten the installation time by direct injection into the cerebrospinal fluid. This allows a good efficiency in less than 10 minutes. It has been shown that low doses of sufentanil (strong opioid) in spinal anesthesia could potentiate the effect of the local anesthetic.
详细描述
Compare the results of obstetric analgesia by sequential combined spinal epidural with local anesthetic injection associated with morphine and a sequential obstetric analgesia by sequential combined spinal epidural with local anesthetic injection alone
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 18 Years 至 40 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •pregnant patients
- •patients who experienced a physiological course of pregnancy
- •patients for which it was estimated eutrophic fetus without pathology found during ultrasound
- •patient consenting to participate to the study
- •patient enrolled in the national healthcare insurance program
- •patient older than 18 years and younger than 40 years
排除标准
- •twin pregnancy
- •contraindication to sequential combined spinal epidural
研究组 & 干预措施
experimental group
sequential combined spinal epidural with local anesthetic injection associated with morphine
干预措施: experimental group : sequential combined spinal epidural with local anesthetic injection (chirocaine) associated with morphine (sufentanil). (Drug)
control group
sequential combined spinal epidural with local anesthetic injection alone
干预措施: control group : sequential combined spinal epidural with local anesthetic injection (chirocaine) alone. (Drug)
结局指标
主要结局
Visual analog pain scale
时间窗: after 5 minutes
Pain evaluated inferior at 3 on 10 using a visual analog pain scale
次要结局
未报告次要终点