Optimization of Physical Focal Stimulation Parameters for Improving Spasticity and Identification of Neurophysiological Mechanism
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Vibration
- Sponsor
- Seoul National University Hospital
- Enrollment
- 17
- Locations
- 1
- Primary Endpoint
- H/M ratio
- Status
- Completed
- Last Updated
- 11 years ago
Overview
Brief Summary
The overall aim of the proposed study is to determine optimal parameter of focal muscle vibration for improving spasticity and identify neurophysiological mechanism in healthy subjects.
In investigation I-1, subjects will undergo focal muscle vibration with 40, 80, 120 Hz frequency at the medial gastrocnemius muscles (mGCM). As a surrogate maker of spasticity, H-reflex and compound motor action potential (CMAP) of the tibial nerve at mGCM will be recorded pre, during, and post vibration.
In investigation I-2, subjects will undergo focal muscle vibration with 0.1, 0.3, 0.5 mm amplitude at mGCM. H-reflex and CMAP of the tibial nerve at mGCM will be recorded pre, during, and post vibration.
In investigation II, subjects will undergo focal muscle vibration with predetermined parameters by the investigation I at mGCM. H-reflex and CMAP of the tibial nerve and motor evoked potential at mGCM will be recorded pre, during, and post vibration.
Investigators
Byung-Mo Oh
Department of Rehabilitation Medicine
Seoul National University Hospital
Eligibility Criteria
Inclusion Criteria
- •Healthy volunteer
Exclusion Criteria
- •Unstable medical conditions
- •History of epilepsy
- •History of drug abuse
Outcomes
Primary Outcomes
H/M ratio
Time Frame: baseline, 1, 5 and 10 minutes during vibration, and 1 and 5 minutes after vibration
The ratio of maximal H-reflex amplitude (mV) to CMAP amplitude (mV) recorded at mGCM
Secondary Outcomes
- M amplitude(baseline, 1, 5 and 10 minutes during vibration, and 1 and 5 minutes after vibration)
- motor evoked potential (MEP) amplitude(baseline, 10 minutes during vibration, and 5 minutes after vibration)
- H amplitude(baseline, 1, 5 and 10 minutes during vibration, and 1 and 5 minutes after vibration)
- Resting motor threshold (RMT)(baseline, 10 minutes during vibration, and 5 minutes after vibration)
- Short interval intracortical inhibition(baseline, 10 minutes during vibration, and 5 minutes after vibration)
- Intracortical facilitation(baseline, 10 minutes during vibration, and 5 minutes after vibration)