Interoceptive fear conditioning and generalization to respiratory sensations in panic disorder patients and healthy controls

• Conditions: anxiety disorder; panic disorder; 10002861

• Registration Number: NL-OMON39913
• Lead Sponsor: niversiteit Maastricht

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 29 April 2024

Recruitment & Eligibility

• Status: Pending
• Sex: Not specified
• Target Recruitment: 80

Inclusion Criteria

Panic patients and healthy volunteers aged between 18-65 years and in a good physical condition

Exclusion Criteria

• History of pulmonary disease (including asthma and lung fibrosis)
• History of cardiovascular disease (including cardiac failure, suspicion of infarct, cardiomyopathy, transient ischemic attack (TIA), angina pectoris, arrythmias)
• Hypertension (diastolic > 100; systolic > 170)
• Personal or familial history of cerebral aneurysm
• Pregnancy
• Epilepsy

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Primary output will be the measures of fear learning to the CS including: the<br /><br>skin conductance response, a potentiated startle blink (EMG), respiration,<br /><br>electrocardiography and self-reported expectancy of the US. The questionnaires<br /><br>(e.g. ASI, PAS, FQ, CLQ, STAI, fear of suffocation) and autobiographical memory<br /><br>will be secondary output variables. A third output variable is the measurement<br /><br>of heart rate variability at rest, derived from a 10 min ECG prior to the<br /><br>experiment.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Not applicable</p><br>