Biological magnetic resonance imaging parameters in cancer

Not Applicable

Completed

• Conditions: Head and Neck Cancer; UKCRC code/ Disease: Cancer/ Malignant neoplasms of lip, oral cavity and pharynx; Specialty: Cancer, Primary sub-specialty: Head and Neck Cancer; Cancer

• Registration Number: ISRCTN12676704
• Lead Sponsor: niversity of Oxford

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2017-08-24
• Study Completion: 2019-05-31
• Last Update Posted: 3 May 2021

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 20

Inclusion Criteria

1. Participant is willing and able to give informed consent for participation in the study
2. Male or female, aged 18 years or above
3. HPV-positive oropharyngeal squamous cell carcinoma for treatment with radical radiotherapy +/- systemic therapy
4. The tumour is at least T2 or if nodal disease is used as the treatment assessment site, the node is at least 2 cm in minimum diameter on MRI
5. In the Investigator’s opinion, is able and willing to comply with all study requirements
6. Willing to allow his or her General Practitioner and consultant, if appropriate, to be notified of participation in the study
7. Involvement in other clinical studies is acceptable

Exclusion Criteria

1. Female participant who is pregnant, lactating or planning pregnancy during the course of the study
2. Significant renal or hepatic impairment
3. Type 1 diabetes mellitus or poorly controlled T2 diabetes mellitus or fasting capillary/venous blood glucose level > 8mmol/L.
4. Ongoing supplemental oxygen as part of clinical care
5. Known lung disease with carbon dioxide retention, chronic obstructive airways disease with known or at risk of hypercapnia
6. Most recent available arterial blood gas (ABG) from the current hospital admission demonstrates hypoxia or hypercapnia on room air
7. Any patient not felt to be suitable for supplemental oxygen or carbogen as considered by an appropriately trained clinician
8. Contraindication to MRI (e.g. cardiac pacemaker, ferromagnetic cerebral aneurysm clip, metallic foreign body in the eye)
9. Any other significant disease or disorder which, in the opinion of the Investigator, may either put the participants at risk because of participation in the study, or may influence the result of the study, or the participant’s ability to participate in the study

Study & Design

• Study Type: Interventional
• Study Design: Not specified