Behaviour of salivary cortisol in kidney failure patients.
- Conditions
- Health Condition 1: N189- Chronic kidney disease, unspecified
- Registration Number
- CTRI/2019/09/021393
- Lead Sponsor
- Department of endocrinology KEM hospital
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Open to Recruitment
- Sex
- Not specified
- Target Recruitment
- 0
1. Patients with clinically stable CKD will be divided on the basis of glomerular filtration rate (GFR) into the following arbitrary four groups: mild (GFR: 60-89 ml/min/1.73 m2), moderate (GFR: 30-59 ml/min/1.73 m2) and severe kidney insufficiency (GFR: 15-29 ml/min/1.73 m2), and patients on haemodialysis. 30 patients from each group, and in addition 30 healthy controls with normal GFR >90 ml/min/1.73 m2) will be recruited.
1. Patients on exogenous steroid therapy.
2. Subjects on drugs known to alter
Dexamethasone metabolism or CBG (cortisol
Binding Globulin) status.
3. Patients having gingivitis or oral ulcers.
4. Oral tobacco use
Exclusion Criteria for Healthy Volunteers:
1. Pregnancy
2. Subjects on drugs known to alter
Dexamethasone metabolism or CBG (cortisol
Binding Globulin) status.
3. Subjects having gingivitis or oral ulcers.
4. Oral tobacco use
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method To derive normative range of salivary cortisol (8 am and 11 pm) in patients with CKD <br/ ><br>Performance of overnight dexamethasone suppressed (ODS) cortisol in patients with CKD <br/ ><br>Timepoint: 12 months
- Secondary Outcome Measures
Name Time Method oneTimepoint: None