octurnal excretion of cortisol, CRH and catecholamines, and their relation to sleep EEG in deployment related posttraumatic stress disorder (PTSD)

Withdrawn

• Conditions: posttraumatic stress disorder; 10002861; trauma; 10040998

• Registration Number: NL-OMON30459
• Lead Sponsor: niversitair Medisch Centrum Utrecht

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 13 May 2024

Recruitment & Eligibility

• Status: Withdrawn
• Sex: Not specified
• Target Recruitment: 60

Inclusion Criteria

male, age 18-65, CAPS > 50 (patients)

Exclusion Criteria

substance /alcoholabuse within 6 months
psychotrophic medication
chronical benzodiazepin use
History of psychiatric disorder (controls), CAPS > 18 (contorls)

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The primary outcome measure is number of awakenings of plasma cortisol<br /><br>concentrations.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Secondary objectives are<br /><br>1. Other PSG parameters<br /><br>2. Nocturnal excretion of catecholamines and hormones of the HPA axis in<br /><br>3. Correlations of plasma concentration of catecholamines and hormones of<br /><br>the HPA axis with number of arousals and other PSG parameters<br /><br>4. Correlation of subjective sleep complaints with number of<br /><br>awakenings and other PSG parameters<br /><br>5. Correlation of objective and subjective sleep quality with<br /><br>general<br /><br>psychological and somatic well being, according to *Symptom<br /><br>Checklist -<br /><br>90* (SCL-90) and *Checklist Individuele Spankracht* (CIS).<br /><br>6. Correlation of sleep endocrinology with temperament and personality,<br /><br>as measured by *Temperament and Character Inventory*.<br /><br>7. Awakening response curve of cortisol and ACTH in PTSD compared with<br /><br>controls</p><br>