Sympathetic activity during carotid sinus massage

• Conditions: Carotid sinus hypersensitivity; Syncope; Fainting; 10007521

• Registration Number: NL-OMON34636
• Lead Sponsor: Academisch Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 6 May 2024

Recruitment & Eligibility

• Status: Pending
• Sex: Not specified
• Target Recruitment: 85

Inclusion Criteria

60 patients from the departments of Medicine and Cardiology who are being analysed for falls and/or episodes of transient loss of consciousness and for whom there is a clinical indication for carotid sinus massage will be studied.
15 patients from the departments of Medicine and Cardiology with proven carotid sinus hypersensitivity
10 healthy volunteers from general population

Exclusion Criteria

- Contra-indications for carotid sinus massage (e.g. carotid bruits recent myocardial or cerebral ischemia, previous ventricular tachyarrhythmias; For the subgroup of 15 patients with established carotid sinus hypersensitivity: cerebrovascular accident or transient ischaemic attack during prior carotid massage)
- presence of any circumstance that is likely to interfere significantly with the use of a tilt table and/or peroneal microneuropgraphy
- for the volunteers: a hierarchical relation to the reaserach group

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>This study intends to describe the changes in sympathetic tone and systemic<br /><br>vascular resistance during carotid sinus massage while supine and head-up<br /><br>tilted. </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>n.a.</p><br>