Study to EvaLuate the EffIcacy and Safety of AbeLacimab in High-risk Patients with Atrial Fibrillation Who Have Been Deemed Unsuitable for Oral AntiCoagulation (LILAC-TIMI 76)
- Registration Number
- NCT05712200
- Lead Sponsor
- Anthos Therapeutics, Inc.
- Brief Summary
A study to evaluate the effect of abelacimab relative to placebo on the rate of ischemic stroke or systemic embolism (SE) in patients with Atrial Fibrillation (AF) who have been deemed by their responsible physicians or by their own decision to be unsuitable for oral anticoagulation therapy.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- RECRUITING
- Sex
- All
- Target Recruitment
- 1900
- Patient is able to understand and has provided written informed consent to participate in the trial
- Diagnosed Atrial Fibrillation (AF) or atrial flutter (documented on an electrocardiogram (ECG) or monitor recording)
- Age 65-74 and a CHA2DS2VASc ≥4 OR age ≥75 and a CHA2DS2VASc ≥3
- Patient is judged by the responsible physician to be unsuitable for oral anticoagulation because the risks outweigh the benefits or the patient is unwilling to take oral anticoagulation AND this determination was made prior to and independent of the study
- At least 1 bleeding risk factor such as severe renal insufficiency, planned daily use of antiplatelet medication for the duration of the trial, history of bleeding from a critical area, or other conditions associated with increased risk of bleeding such as chronic nonsteroidal anti-inflammatory drug (NSAID) use, frailty or multiple falls
- Patient is judged by the responsible physician to be unsuitable for left atrial appendage (LAA) closure or occlusion device, an approved device is not available, or the patient is unwilling to undergo the procedure AND this determination was made prior to and independent of the study
- AF due to an ongoing acute reversible cause (e.g., cardiac surgery, pulmonary embolism (PE), untreated hyperthyroidism, alcohol use)
- Patients who within 60 days prior to randomization (1) received a vitamin K antagonists (VKA) (e.g., warfarin, phenprocoumon, acenocoumarol) or a direct oral anticoagulant (DOAC) such as, dabigatran, rivaroxaban, apixaban, or edoxaban or (2) were newly diagnosed with AF
- Patients with an intracranial or intraocular bleed within the 3 months prior to screening or any history of spontaneous intracerebral hemorrhage at any time in the absence of antithrombotic treatment
- Any stroke within 14 days before randomization or transient ischemic attack (TIA) within 3 days before randomization
- Mechanical heart valve or valve disease that is expected to require mechanical valve replacement intervention (surgical or invasive) during the course of the study
Other protocol defined Inclusion/Exclusion criteria may apply
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Abelacimab (MAA868) Abelacimab Patients will be randomized in a 1:1 ratio to receive abelacimab 150 mg subcutaneous (SC) or matching placebo once monthly. Placebo Placebo Patients will be randomized in a 1:1 ratio to receive abelacimab 150 mg subcutaneous (SC) or matching placebo once monthly.
- Primary Outcome Measures
Name Time Method Efficacy: Time to first event of ischemic stroke or systemic embolism (SE) Up to 30 months Safety: Time to first occurrence of Bleeding Academic Research Consortium (BARC) type 3c/5 bleeding Up to 30 months
- Secondary Outcome Measures
Name Time Method Efficacy: All-cause mortality Up to 30 months Efficacy: Cardiovascular (CV) mortality Up to 30 months Efficacy: Time to first event of ischemic stroke, systemic embolism (SE), or Bleeding Academic Research Consortium (BARC) type 3c/5 bleeding event Up to 30 months Efficacy: Time to first event of ischemic stroke, systemic embolism (SE), myocardial infarctions (MI), venous thromboembolism (VTE), or acute limb ischemia Up to 30 months Abelacimab versus placebo with regard to the composite of ischemic stroke, SE, MI, VTE, or acute limb ischemia
Time to first event of ischemic stroke, systemic embolism (SE), myocardial infarctions (MI), venous thromboembolism (VTE), acute limb ischemia, or International Society on Thrombosis and Haemostasis (ISTH) major bleeding Up to 30 months Abelacimab versus placebo with regard to net clinical outcome defined as the composite of ischemic stroke, SE, MI, VTE, acute limb ischemia, or International Society on Thrombosis and Haemostasis (ISTH) major bleeding
Trial Locations
- Locations (427)
Anthos Investigative Site 1505
🇧🇷Blumenau, Brazil
Anthos Investigative Site 1535
🇧🇷Brasília, Brazil
Anthos Investigative Site 1501
🇧🇷Campina Grande Do Sul, Brazil
Anthos Investigative Site 1503
🇧🇷Campinas, Brazil
Anthos Investigative Site 1522
🇧🇷Campinas, Brazil
Anthos Investigative Site 1520
🇧🇷Campo Grande, Brazil
Anthos Investigative Site 1532
🇧🇷Canoas, Brazil
Anthos Investigative Site 1526
🇧🇷Caxias Do Sul, Brazil
Anthos Investigative Site 1540
🇧🇷Curitiba, Brazil
Anthos Investigative Site 1509
🇧🇷Curitiba, Brazil
Anthos Investigative Site 1525
🇧🇷Goiânia, Brazil
Anthos Investigative Site 1502
🇧🇷Marília, Brazil
Anthos Investigative Site 1533
🇧🇷Passo Fundo, Brazil
Anthos Investigative Site 1517
🇧🇷Porto Alegre, Brazil
Anthos Investigative Site 1519
🇧🇷Porto Alegre, Brazil
Anthos Investigative Site 1506
🇧🇷Porto Alegre, Brazil
Anthos Investigative Site 1530
🇧🇷Porto Alegre, Brazil
Anthos Investigative Site 1512
🇧🇷Porto Alegre, Brazil
Anthos Investigative Site 1524
🇧🇷Porto Alegre, Brazil
Anthos Investigative Site 1508
🇧🇷Porto Alegre, Brazil
Anthos Investigative Site 1531
🇧🇷Recife, Brazil
Anthos Investigative Site 1515
🇧🇷Ribeirão Preto, Brazil
Anthos Investigative Site 1536
🇧🇷Ribeirão Preto, Brazil
Anthos Investigative Site 1537
🇧🇷Rio De Janeiro, Brazil
Anthos Investigative Site 1510
🇧🇷Salvador, Brazil
Anthos Investigative Site 1521
🇧🇷Salvador, Brazil
Anthos Investigative Site 1534
🇧🇷São Paulo, Brazil
Anthos Investigative Site 1511
🇧🇷São Paulo, Brazil
Anthos Investigative Site 1538
🇧🇷São Paulo, Brazil
Anthos Investigative Site 1539
🇧🇷São Paulo, Brazil
Anthos Investigative Site 1529
🇧🇷São Paulo, Brazil
Anthos Investigative Site 1514
🇧🇷Tatuí, Brazil
Anthos Investigative Site 1541
🇧🇷Teresina, Brazil
Anthos Investigative Site 1504
🇧🇷Votuporanga, Brazil
Anthos Investigative Site 6014
🇧🇬Blagoevgrad, Bulgaria
Anthos Investigative Site 6026
🇧🇬Burgas, Bulgaria
Anthos Investigative Site 6019
🇧🇬Gabrovo, Bulgaria
Anthos Investigative Site 6018
🇧🇬Haskovo, Bulgaria
Anthos Investigative Site 6013
🇧🇬Panagyurishte, Bulgaria
Anthos Investigative Site 6025
🇧🇬Pazardzhik, Bulgaria
Anthos Investigative Site 6006
🇧🇬Pleven, Bulgaria
Anthos Investigative Site 6003
🇧🇬Pleven, Bulgaria
Anthos Investigative Site 6007
🇧🇬Plovdiv, Bulgaria
Anthos Investigative Site 6008
🇧🇬Plovdiv, Bulgaria
Anthos Investigative Site 6009
🇧🇬Plovdiv, Bulgaria
Anthos Investigative Site 6004
🇧🇬Plovdiv, Bulgaria
Anthos Investigative Site 6021
🇧🇬Plovdiv, Bulgaria
Anthos Investigative Site 6027
🇧🇬Sliven, Bulgaria
Anthos Investigative Site 6022
🇧🇬Smolyan, Bulgaria
Anthos Investigative Site 6028
🇧🇬Sofia, Bulgaria
Anthos Investigative Site 6024
🇧🇬Sofia, Bulgaria
Anthos Investigative Site 6023
🇧🇬Sofia, Bulgaria
Anthos Investigative Site 6010
🇧🇬Sofia, Bulgaria
Anthos Investigative Site 6015
🇧🇬Sofia, Bulgaria
Anthos Investigative Site 6020
🇧🇬Sofia, Bulgaria
Anthos Investigative Site 6001
🇧🇬Sofia, Bulgaria
Anthos Investigative Site 6017
🇧🇬Sofia, Bulgaria
Anthos Investigative Site 6012
🇧🇬Sofia, Bulgaria
Anthos Investigative Site 6002
🇧🇬Sofia, Bulgaria
Anthos Investigative Site 6011
🇧🇬Stara Zagora, Bulgaria
Anthos Investigative Site 1801
🇨🇳Hangzhou, China
Anthos Investigative Site 1808
🇨🇳Hangzhou, China
Anthos Investigative Site 1816
🇨🇳Jinan, China
Anthos Investigative Site 1804
🇨🇳Lianyungang, China
Anthos Investigative Site 1814
🇨🇳Luoyang, China
Anthos Investigative Site 1817
🇨🇳Nanchang, China
Anthos Investigative Site 1820
🇨🇳Nanchang, China
Anthos Investigative Site 1803
🇨🇳Nanjing, China
Anthos Investigative Site 1815
🇨🇳Ningbo, China
Anthos Investigative Site 1819
🇨🇳Shijiazhuang, China
Anthos Investigative Site 1812
🇨🇳Tianjin, China
Anthos Investigative Site 1813
🇨🇳Yangzhou, China
Anthos Investigative Site 1805
🇨🇳Yinchuan, China
Anthos Investigative Site 3002
🇨🇿Brandýs Nad Labem, Czechia
Anthos Investigative Site 3006
🇨🇿Liberec, Czechia
Anthos Investigative Site 3007
🇨🇿Ostrava - Poruba, Czechia
Anthos Investigative Site 3001
🇨🇿Poděbrady, Czechia
Anthos Investigative Site 3003
🇨🇿Prague, Czechia
Anthos Investigative Site 3005
🇨🇿Praha, Czechia
Anthos Investigative Site 3004
🇨🇿Praha, Czechia
Anthos Investigative Site 3010
🇨🇿Praha, Czechia
Anthos Investigative Site 3009
🇨🇿Trutnov, Czechia
Anthos Investigative Site 3011
🇨🇿Ústí Nad Labem, Czechia
Anthos Investigative Site 2203
🇪🇪Tallinn, Estonia
Anthos Investigative Site 2202
🇪🇪Tallinn, Estonia
Anthos Investigative Site 2201
🇪🇪Tallinn, Estonia
Anthos Investigative Site 7006
🇩🇪Altenburg, Germany
Anthos Investigative Site 7014
🇩🇪Berlin, Germany
Anthos Investigative Site 7004
🇩🇪Dresden, Germany
Anthos Investigative Site 7012
🇩🇪Hamburg, Germany
Anthos Investigative Site 7003
🇩🇪Hamburg, Germany
Anthos Investigative Site 7013
🇩🇪Hannover, Germany
Anthos Investigative Site 7009
🇩🇪Ludwigshafen, Germany
Anthos Investigative Site 7002
🇩🇪Markkleeberg, Germany
Anthos Investigative Site 7007
🇩🇪Paderborn, Germany
Anthos Investigative Site 7001
🇩🇪Schwerin, Germany
Anthos Investigative Site 4015
🇭🇺Budapest, Hungary
Anthos Investigative Site 4006
🇭🇺Budapest, Hungary
Anthos Investigative Site 4009
🇭🇺Budapest, Hungary
Anthos Investigative Site 4002
🇭🇺Békéscsaba, Hungary
Anthos Investigative Site 4011
🇭🇺Gyöngyös, Hungary
Anthos Investigative Site 4012
🇭🇺Kaposvar, Hungary
Anthos Investigative Site 4007
🇭🇺Kistarcsa, Hungary
Anthos Investigative Site 4005
🇭🇺Nyíregyháza, Hungary
Anthos Investigative Site 4010
🇭🇺Pécs, Hungary
Anthos Investigative Site 4017
🇭🇺Szeged, Hungary
Anthos Investigative Site 4016
🇭🇺Veszprém, Hungary
Anthos Investigative Site 4008
🇭🇺Zalaegerszeg, Hungary
Anthos Investigative Site 2310
🇮🇳Ahmedabad, India
Anthos Investigative Site 2320
🇮🇳Ahmedabad, India
Anthos Investigative Site 2311
🇮🇳Bangalore, India
Anthos Investigative Site 2318
🇮🇳Bhubaneswar, India
Anthos Investigative Site 2303
🇮🇳Chandigarh, India
Anthos Investigative Site 2308
🇮🇳Ghaziabad, India
Anthos Investigative Site 2306
🇮🇳Jaipur, India
Anthos Investigative Site 2304
🇮🇳Kochi, India
Anthos Investigative Site 2314
🇮🇳Kolkata, India
Anthos Investigative Site 2313
🇮🇳Mumbai, India
Anthos Investigative Site 2315
🇮🇳Nagpur, India
Anthos Investigative Site 2316
🇮🇳Nagpur, India
Anthos Investigative Site 2307
🇮🇳New Delhi, India
Anthos Investigative Site 2301
🇮🇳New Delhi, India
Anthos Investigative Site 2319
🇮🇳New Delhi, India
Anthos Investigative Site 2305
🇮🇳Pune, India
Anthos Investigative Site 2317
🇮🇳Pune, India
Anthos Investigative Site 2309
🇮🇳Secunderabad, India
Anthos Investigative Site 2312
🇮🇳Visakhapatnam, India
Anthos Investigative Site 2321
🇮🇳Visakhapatnam, India
Anthos Investigative Site 1210
🇮🇱Afula, Israel
Anthos Investigative Site 1205
🇮🇱Ashkelon, Israel
Anthos Investigative Site 1206
🇮🇱Hadera, Israel
Anthos Investigative Site 1211
🇮🇱Haifa, Israel
Anthos Investigative Site 1201
🇮🇱Haifa, Israel
Anthos Investigative Site 1209
🇮🇱H̱olon, Israel
Anthos Investigative Site 1204
🇮🇱Kfar Saba, Israel
Anthos Investigative Site 1202
🇮🇱Nahariya, Israel
Anthos Investigative Site 1207
🇮🇱Petah tikva, Israel
Anthos Investigative Site 1203
🇮🇱Reẖovot, Israel
Anthos Investigative Site 1208
🇮🇱Zefat, Israel
Anthos Investigative Site 8016
🇮🇹Ancona, Italy
Anthos Investigative Site 8003
🇮🇹Bologna, Italy
Anthos Investigative Site 8015
🇮🇹Brescia, Italy
Anthos Investigative Site 8019
🇮🇹Caserta, Italy
Anthos Investigative Site 8008
🇮🇹Catanzaro, Italy
Anthos Investigative Site 8013
🇮🇹Lecco, Italy
Anthos Investigative Site 8001
🇮🇹Milano, Italy
Anthos Investigative Site 8007
🇮🇹Milan, Italy
Anthos Investigative Site 8017
🇮🇹Palermo, Italy
Anthos Investigative Site 8010
🇮🇹Roma, Italy
Anthos Investigative Site 8011
🇮🇹Roma, Italy
Anthos Investigative Site 8002
🇮🇹Roma, Italy
Anthos Investigative Site 8004
🇮🇹Saronno, Italy
Anthos Investigative Site 8005
🇮🇹Sesto San Giovanni, Italy
Anthos Investigative Site 8014
🇮🇹Torino, Italy
Anthos Investigative Site 8006
🇮🇹Varese, Italy
Anthos Investigative Site 8009
🇮🇹Vittoria, Italy
Anthos Investigative Site 1908
🇯🇵Chikushino-shi, Japan
Anthos Investigative Site 1902
🇯🇵Chuo-Ku, Japan
Anthos Investigative Site 1920
🇯🇵Funabashi-Shi, Japan
Anthos Investigative Site 1910
🇯🇵Hamada-shi, Japan
Anthos Investigative Site 1906
🇯🇵Himeji-Shi, Japan
Anthos Investigative Site 1911
🇯🇵Imabari-shi, Japan
Anthos Investigative Site 1912
🇯🇵Isehara-Shi, Japan
Anthos Investigative Site 1921
🇯🇵Koto-Ku, Japan
Anthos Investigative Site 1915
🇯🇵Kure-shi, Japan
Anthos Investigative Site 1903
🇯🇵Matsumoto-Shi, Japan
Anthos Investigative Site 1907
🇯🇵Nagano-Shi, Japan
Anthos Investigative Site 1922
🇯🇵Sapporo-shi, Japan
Anthos Investigative Site 1904
🇯🇵Sendai-shi, Japan
Anthos Investigative Site 1913
🇯🇵Shimonoseki-shi, Japan
Anthos Investigative Site 1914
🇯🇵Tachikawa-shi, Japan
Anthos Investigative Site 1909
🇯🇵Tochigi, Japan
Anthos Investigative Site 1901
🇯🇵Urayasu, Japan
Anthos Investigative Site 1917
🇯🇵Uwajima-Shi, Japan
Anthos Investigative Site 1918
🇯🇵Yokohama-shi, Japan
Anthos Investigative Site 1919
🇯🇵Yokohama-Shi, Japan
Anthos Investigative Site 1916
🇯🇵Yokohama-Shi, Japan
Anthos Investigative Site 2103
🇱🇻Baldone, Latvia
Anthos Investigative Site 2109
🇱🇻Balvi, Latvia
Anthos Investigative Site 2107
🇱🇻Daugavpils, Latvia
Anthos Investigative Site 2108
🇱🇻Limbazi, Latvia
Anthos Investigative Site 2110
🇱🇻Riga, Latvia
Anthos Investigative Site 2101
🇱🇻Riga, Latvia
Anthos Investigative Site 2105
🇱🇻Riga, Latvia
Anthos Investigative Site 2102
🇱🇻Riga, Latvia
Anthos Investigative Site 2111
🇱🇻Sigulda, Latvia
Anthos Investigative Site 2104
🇱🇻Valmiera, Latvia
Anthos Investigative Site 2106
🇱🇻Valmiera, Latvia
Anthos Investigative Site 1701
🇲🇽Aguascalientes, Mexico
Anthos Investigative Site 1707
🇲🇽Aguascalientes, Mexico
Anthos Investigative Site 1713
🇲🇽Aguascalientes, Mexico
Anthos Investigative Site 1721
🇲🇽Chihuahua, Mexico
Anthos Investigative Site 1712
🇲🇽Ciudad De México, Mexico
Anthos Investigative Site 1703
🇲🇽Culiacán, Mexico
Anthos Investigative Site 1715
🇲🇽Guadalajara, Mexico
Anthos Investigative Site 1711
🇲🇽Guerrero, Mexico
Anthos Investigative Site 1704
🇲🇽Monterrey, Mexico
Anthos Investigative Site 1705
🇲🇽Monterrey, Mexico
Anthos Investigative Site 1719
🇲🇽Monterrey, Mexico
Anthos Investigative Site 1702
🇲🇽Querétaro, Mexico
Anthos Investigative Site 1718
🇲🇽San Luis Potosí, Mexico
Anthos Investigative Site 1716
🇲🇽Tlalpan, Mexico
Anthos Investigative Site 1706
🇲🇽Veracruz, Mexico
Anthos Investigative Site 1708
🇲🇽Veracruz, Mexico
Anthos Investigative Site 1709
🇲🇽Xalapa, Mexico
Anthos Investigative Site 5022
🇵🇱Czeladź, Poland
Anthos Investigative Site 5003
🇵🇱Katowice, Poland
Anthos Investigative Site 5009
🇵🇱Katowice, Poland
Anthos Investigative Site 5005
🇵🇱Katowice, Poland
Anthos Investigative Site 5016
🇵🇱Kraków, Poland
Anthos Investigative Site 5018
🇵🇱Kraków, Poland
Anthos Investigative Site 5023
🇵🇱Lublin, Poland
Anthos Investigative Site 5006
🇵🇱Lublin, Poland
Anthos Investigative Site 5008
🇵🇱Olsztyn, Poland
Anthos Investigative Site 5025
🇵🇱Oświęcim, Poland
Anthos Investigative Site 5002
🇵🇱Przemyśl, Poland
Anthos Investigative Site 5004
🇵🇱Rzeszów, Poland
Anthos Investigative Site 5001
🇵🇱Tychy, Poland
Anthos Investigative Site 5014
🇵🇱Warszawa, Poland
Anthos Investigative Site 5017
🇵🇱Warszawa, Poland
Anthos Investigative Site 5011
🇵🇱Warszawa, Poland
Anthos Investigative Site 5015
🇵🇱Warszawa, Poland
Anthos Investigative Site 5019
🇵🇱Wrocław, Poland
Anthos Investigative Site 5007
🇵🇱Wrocław, Poland
Anthos Investigative Site 5012
🇵🇱Łódź, Poland
Anthos Investigative Site 5028
🇵🇱Łódź, Poland
Anthos Investigative Site 9022
🇷🇴Baloteşti, Romania
Anthos Investigative Site 9001
🇷🇴Brăila, Romania
Anthos Investigative Site 9023
🇷🇴Bucharest, Romania
Anthos Investigative Site 9019
🇷🇴Bucuresti, Romania
Anthos Investigative Site 9024
🇷🇴Cluj-Napoca, Romania
Anthos Investigative Site 9017
🇷🇴Craiova, Romania
Anthos Investigative Site 9006
🇷🇴Craiova, Romania
Anthos Investigative Site 9010
🇷🇴Oradea, Romania
Anthos Investigative Site 9025
🇷🇴Piteşti, Romania
Anthos Investigative Site 9014
🇷🇴Piteşti, Romania
Anthos Investigative Site 9012
🇷🇴Satu Mare, Romania
Anthos Investigative Site 9007
🇷🇴Timişoara, Romania
Anthos Investigative Site 9005
🇷🇴Timişoara, Romania
Anthos Investigative Site 9018
🇷🇴Timişoara, Romania
Anthos Investigative Site 9013
🇷🇴Timişoara, Romania
Anthos Investigative Site 9008
🇷🇴Timişoara, Romania
Anthos Investigative Site 9003
🇷🇴Târgu-Mureş, Romania
Anthos Investigative Site 9004
🇷🇴Târgu-Mureş, Romania
Anthos Investigative Site 9016
🇷🇴Târgu-Mureş, Romania
Anthos Investigative Site 9021
🇷🇴Târgu-Mureş, Romania
Anthos Investigative Site 2411
🇿🇦Bellville, South Africa
Anthos Investigative Site 2409
🇿🇦Benoni, South Africa
Anthos Investigative Site 2402
🇿🇦Pretoria, South Africa
Anthos Investigative Site 2405
🇿🇦Tongaat, South Africa
Anthos Investigative Site 1108
🇪🇸A Coruña, Spain
Anthos Investigative Site 1116
🇪🇸Almería, Spain
Anthos Investigative Site 1121
🇪🇸Barcelona, Spain
Anthos Investigative Site 1120
🇪🇸Barcelona, Spain
Anthos Investigative Site 1109
🇪🇸Cabra, Spain
Anthos Investigative Site 1103
🇪🇸Granada, Spain
Anthos Investigative Site 1111
🇪🇸Jaén, Spain
Anthos Investigative Site 1118
🇪🇸León, Spain
Anthos Investigative Site 1104
🇪🇸Madrid, Spain
Anthos Investigative Site 1117
🇪🇸Madrid, Spain
Anthos Investigative Site 1106
🇪🇸Madrid, Spain
Anthos Investigative Site 1113
🇪🇸Madrid, Spain
Anthos Investigative Site 1110
🇪🇸Murcia, Spain
Anthos Investigative Site 1105
🇪🇸Málaga, Spain
Anthos Investigative Site 1115
🇪🇸Oviedo, Spain
Anthos Investigative Site 1107
🇪🇸Santiago De Compostela, Spain
Anthos Investigative Site 1102
🇪🇸Sevilla, Spain
Anthos Investigative Site 1122
🇪🇸Sevilla, Spain
Anthos Investigative Site 1112
🇪🇸Terrassa, Spain
Anthos Investigative Site 1101
🇪🇸Valencia, Spain
Anthos Investigative Site 1119
🇪🇸Vigo, Spain
Anthos Investigative Site 1303
🇬🇧Corby, United Kingdom
Anthos Investigative Site 1313
🇬🇧Glasgow, United Kingdom
Anthos Investigative Site 1315
🇬🇧Hayle, United Kingdom
Anthos Investigative Site 1802
🇨🇳Chengdu, China
Anthos Investigative Site 1809
🇨🇳Haidian, China
Anthos Investigative Site 1513
🇧🇷Blumenau, Brazil
Anthos Investigative Site 9911
🇺🇸The Villages, Florida, United States
Anthos Investigative Site 9909
🇺🇸Webster, Texas, United States
Anthos Investigative Site 1411
🇦🇷Buenos Aires, Argentina
Anthos Investigative Site 1410
🇦🇷Ciudad Autónoma de Buenos Aire, Argentina
Anthos Investigative Site 2325
🇮🇳Chennai, India
Anthos Investigative Site 2329
🇮🇳Meerut, India
Anthos Investigative Site 2408
🇿🇦Centurion, South Africa
Anthos Investigative Site 1040
🇺🇸Birmingham, Alabama, United States
Anthos Investigative Site 1041
🇺🇸Mobile, Alabama, United States
Anthos Investigative Site 1089
🇺🇸Gilbert, Arizona, United States
Anthos Investigative Site 1099
🇺🇸Peoria, Arizona, United States
Anthos Investigative Site 9906
🇺🇸Phoenix, Arizona, United States
Anthos Investigative Site 1078
🇺🇸Loma Linda, California, United States
Anthos Investigative Site 1077
🇺🇸Los Angeles, California, United States
Anthos Investigative Site 1015
🇺🇸Northridge, California, United States
Anthos Investigative Site 1070
🇺🇸Redding, California, United States
Anthos Investigative Site 1071
🇺🇸San Dimas, California, United States
Anthos Investigative Site 1076
🇺🇸Santa Ana, California, United States
Anthos Investigative Site 9907
🇺🇸Vista, California, United States
Anthos Investigative Site 1095
🇺🇸Aurora, Colorado, United States
Anthos Investigative Site 1049
🇺🇸Denver, Colorado, United States
Anthos Investigative Site 1012
🇺🇸Stamford, Connecticut, United States
Anthos Investigative Site 1013
🇺🇸Boca Raton, Florida, United States
Anthos Investigative Site 1025
🇺🇸Clearwater, Florida, United States
Anthos Investigative Site 1022
🇺🇸Clearwater, Florida, United States
Anthos Investigative Site 1019
🇺🇸Daytona Beach, Florida, United States
Anthos Investigative Site 1083
🇺🇸Hollywood, Florida, United States
Anthos Investigative Site 1008
🇺🇸Jacksonville, Florida, United States
Anthos Investigative Site 9904
🇺🇸Lake Mary, Florida, United States
Anthos Investigative Site 1093
🇺🇸Lutz, Florida, United States
Anthos Investigative Site 1072
🇺🇸Miami Lakes, Florida, United States
Anthos Investigative Site 1067
🇺🇸Ormond Beach, Florida, United States
Anthos Investigative Site 1026
🇺🇸Safety Harbor, Florida, United States
Anthos Investigative Site 1002
🇺🇸Saint Augustine, Florida, United States
Anthos Investigative Site 1004
🇺🇸Saint Augustine, Florida, United States
Anthos Investigative Site 1044
🇺🇸Tamarac, Florida, United States
Anthos Investigative Site 1088
🇺🇸Tamarac, Florida, United States
Anthos Investigative Site 1046
🇺🇸Tampa, Florida, United States
Anthos Investigative Site 1052
🇺🇸Lithonia, Georgia, United States
Anthos Investigative Site 1033
🇺🇸Macon, Georgia, United States
Anthos Investigative Site 1042
🇺🇸Norcross, Georgia, United States
Anthos Investigative Site 1003
🇺🇸Suwanee, Georgia, United States
Anthos Investigative Site 1030
🇺🇸Park Ridge, Illinois, United States
Anthos Investigative Site 1098
🇺🇸Merrillville, Indiana, United States
Anthos Investigative Site 1016
🇺🇸Wichita, Kansas, United States
Anthos Investigative Site 1006
🇺🇸Alexandria, Louisiana, United States
Anthos Investigative Site 1043
🇺🇸Shreveport, Louisiana, United States
Anthos Investigative Site 1054
🇺🇸Bangor, Maine, United States
Anthos Investigative Site 1039
🇺🇸Baltimore, Maryland, United States
Anthos Investigative Site 1023
🇺🇸Lanham, Maryland, United States
Anthos Investigative Site 1028
🇺🇸Rockville, Maryland, United States
Anthos Investigative Site 1082
🇺🇸Boston, Massachusetts, United States
Anthos Investigative Site 1021
🇺🇸Lansing, Michigan, United States
Anthos Investigative Site 1059
🇺🇸Southgate, Michigan, United States
Anthos Investigative Site 1017
🇺🇸Tupelo, Mississippi, United States
Anthos Investigative Site 1080
🇺🇸Kansa City, Missouri, United States
Anthos Investigative Site 1066
🇺🇸Lincoln, Nebraska, United States
Anthos Investigative Site 1036
🇺🇸Las Vegas, Nevada, United States
Anthos Investigative Site 1094
🇺🇸Englewood, New Jersey, United States
Anthos Investigative Site 9905
🇺🇸Brooklyn, New York, United States
Anthos Investigative Site 1014
🇺🇸Middletown, New York, United States
Anthos Investigative Site 1037
🇺🇸Rosedale, New York, United States
Anthos Investigative Site 1065
🇺🇸Cary, North Carolina, United States
Anthos Investigative Site 1005
🇺🇸Charlotte, North Carolina, United States
Anthos Investigative Site 1048
🇺🇸Fayetteville, North Carolina, United States
Anthos Investigative Site 1035
🇺🇸Henderson, North Carolina, United States
Anthos Investigative Site 1001
🇺🇸Lenoir, North Carolina, United States
Anthos Investigative Site 9902
🇺🇸Beavercreek, Ohio, United States
Anthos Investigative Site 1075
🇺🇸Portland, Oregon, United States
Anthos Investigative Site 1074
🇺🇸Bristol, Pennsylvania, United States
Anthos Investigative Site 1087
🇺🇸Horsham, Pennsylvania, United States
Anthos Investigative Site 1032
🇺🇸Rock HIll, South Carolina, United States
Anthos Investigative Site 1050
🇺🇸Elizabethton, Tennessee, United States
Anthos Investigative Site 1057
🇺🇸Germantown, Tennessee, United States
Anthos Investigative Site 1056
🇺🇸Memphis, Tennessee, United States
Anthos Investigative Site 9913
🇺🇸Beaumont, Texas, United States
Anthos Investigative Site 1091
🇺🇸El Paso, Texas, United States
Anthos Investigative Site 1069
🇺🇸Houston, Texas, United States
Anthos Investigative Site 1068
🇺🇸Houston, Texas, United States
Anthos Investigative Site 1097
🇺🇸Houston, Texas, United States
Anthos Investigative Site 9903
🇺🇸Houston, Texas, United States
Anthos Investigative Site 1053
🇺🇸Houston, Texas, United States
Anthos Investigative Site 1064
🇺🇸Houston, Texas, United States
Anthos Investigative Site 9901
🇺🇸Laredo, Texas, United States
Anthos Investigative Site 1063
🇺🇸McAllen, Texas, United States
Anthos Investigative Site 1096
🇺🇸McKinney, Texas, United States
Anthos Investigative Site 1079
🇺🇸McKinney, Texas, United States
Anthos Investigative Site 1024
🇺🇸Odessa, Texas, United States
Anthos Investigative Site 1085
🇺🇸Port Arthur, Texas, United States
Anthos Investigative Site 1090
🇺🇸Sugar Land, Texas, United States
Anthos Investigative Site 1011
🇺🇸Tomball, Texas, United States
Anthos Investigative Site 1060
🇺🇸Waco, Texas, United States
Anthos Investigative Site 1092
🇺🇸Wylie, Texas, United States
Anthos Investigative Site 1084
🇺🇸American Fork, Utah, United States
Anthos Investigative Site 1031
🇺🇸Bountiful, Utah, United States
Anthos Investigative Site 1029
🇺🇸Holladay, Utah, United States
Anthos Investigative Site 1038
🇺🇸Pleasant View, Utah, United States
Anthos Investigative Site 1034
🇺🇸Roy, Utah, United States
Anthos Investigative Site 1018
🇺🇸Falls Church, Virginia, United States
Anthos Investigative Site 1010
🇺🇸Manassas, Virginia, United States
Anthos Investigative Site 1009
🇺🇸Roanoke, Virginia, United States
Anthos Investigative Site 1073
🇺🇸Tacoma, Washington, United States
Anthos Investigative Site 1409
🇦🇷Ciudad Autónoma Buenos Aires, Argentina
Anthos Investigative Site 1404
🇦🇷San Miguel De Tucumán, Argentina
Anthos Investigative Site 1518
🇧🇷Aracaju, Brazil
Anthos Investigative Site 1527
🇧🇷Belo Horizonte, Brazil
Anthos Investigative Site 1528
🇧🇷Belo Horizonte, Brazil
Anthos Investigative Site 1516
🇧🇷Belo Horizonte, Brazil
Anthos Investigative Site 1507
🇧🇷Belo Horizonte, Brazil
Anthos Investigative Site 2012
🇨🇦Mira Road, Nova Scotia, Canada
Anthos Investigative Site 2003
🇨🇦Cambridge, Ontario, Canada
Anthos Investigative Site 2007
🇨🇦Chicoutimi, Quebec, Canada
Anthos Investigative Site 2010
🇨🇦Sherbrooke, Quebec, Canada
Anthos Investigative Site 2016
🇨🇦Abbotsford, Canada
Anthos Investigative Site 2019
🇨🇦Brampton, Canada
Anthos Investigative Site 2015
🇨🇦Edmonton, Canada
Anthos Investigative Site 2018
🇨🇦Greenfield Park, Canada
Anthos Investigative Site 2005
🇨🇦Halifax, Canada
Anthos Investigative Site 2014
🇨🇦Montréal, Canada
Anthos Investigative Site 2004
🇨🇦New Westminster, Canada
Anthos Investigative Site 2021
🇨🇦North Vancouver, Canada
Anthos Investigative Site 2002
🇨🇦Québec, Canada
Anthos Investigative Site 2006
🇨🇦Saint-Jérôme, Canada
Anthos Investigative Site 2022
🇨🇦Thunder Bay, Canada
Anthos Investigative Site 2017
🇨🇦Toronto, Canada
Anthos Investigative Site 1605
🇨🇱Concepción, Chile
Anthos Investigative Site 1606
🇨🇱Independencia, Chile
Anthos Investigative Site 1604
🇨🇱Providencia, Chile
Anthos Investigative Site 1607
🇨🇱San Bernardo, Chile
Anthos Investigative Site 1609
🇨🇱San Miguel, Chile
Anthos Investigative Site 1608
🇨🇱Santiago, Chile
Anthos Investigative Site 1610
🇨🇱Talcahuano, Chile
Anthos Investigative Site 1603
🇨🇱Temuco, Chile
Anthos Investigative Site 1602
🇨🇱Temuco, Chile
Anthos Investigative Site 1601
🇨🇱Viña Del Mar, Chile
Anthos Investigative Site 1818
🇨🇳Changchun, China
Anthos Investigative Site 1810
🇨🇳Changsha, China
Anthos Investigative Site 1811
🇨🇳Changsha, China
Anthos Investigative Site 1311
🇬🇧High Wycombe, United Kingdom
Anthos Investigative Site 1301
🇬🇧Isleworth, United Kingdom
Anthos Investigative Site 1316
🇬🇧King's Lynn, United Kingdom
Anthos Investigative Site 1309
🇬🇧Leeds, United Kingdom
Anthos Investigative Site 1314
🇬🇧London, United Kingdom
Anthos Investigative Site 1308
🇬🇧London, United Kingdom
Anthos Investigative Site 1312
🇬🇧Manchester, United Kingdom
Anthos Investigative Site 1307
🇬🇧Newcastle Upon Tyne, United Kingdom
Anthos Investigative Site 1305
🇬🇧Peterborough, United Kingdom
Anthos Investigative Site 1302
🇬🇧Stevenage, United Kingdom
Anthos Investigative Site 1310
🇬🇧Stockton-on-Tees, United Kingdom
Anthos Investigative Site 1306
🇬🇧Taunton, United Kingdom
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