Comparative study of Magnesium sulphate nebulization and Lignocaine nebulization in prevention of postoperative sore throat (POST), Hoarseness of voice and Cough in patients undergoing general anaesthesia
试验速览
- 阶段
- 3 期
- 状态
- 尚未招募
- 发起方
- 入组人数
- 90
- 试验地点
- 1
- 主要终点
- To assess incidence and severity of postoperative sore throat, hoarseness of voice and cough.
研究概览
简要总结
This will be prospective double blind study performed to evaluate and compare efficacy of preoperative magnesium sulphate 250mg and lignocaine 2% nebulization on the incidence and severity of postoperative sore throat, hoarseness of voice and cough in the patients undergoing surgeries under general anaesthesia with endotracheal intubation.primary objective is to assess incidence and severity of postoperative sore throat,hoarseness of voice and cough immediately after extubation followed by evert 2nd hourly till 6th hourly,12th and 24th hour.secondary objectives are haemodynamic changes like HR,SBP,DBP, MAP and SPO2.
研究设计
- 研究类型
- Interventional
- 分配方式
- Computer generated randomization
- 盲法
- Participant and Investigator Blinded
入排标准
- 年龄范围
- 18.00 Year(s) 至 60.00 Year(s)（—）
- 性别
- All
入选标准
- •patients undergoing general anaesthesia in supine position.
- •duration of surgery up to 3 hours 3)ASA physical status 1&2.
排除标准
- •ASA class 3 and above 2)Mallampatti grades more than 2 3) any psychiatric disorders and history of epilepsy 4)neurological patients with raised intracranial pressure 5) patients with known CAD and IHD 6)pregnancy 7) patients sensitive or allergic to study drug.
结局指标
主要结局
To assess incidence and severity of postoperative sore throat, hoarseness of voice and cough.
时间窗: To monitor effects immediately after extubation followed by every 2nd hourly till 6th hours thereafter every 12 hours and 24 hour postoperative.
次要结局
- Haemodynamic changes HR,SBP,DBP,MAP & SPO2 Side effects(Hemodynamic monitoring in 1) prenebulization 2)Preinduction 3)postoperative immediately followed by 2nd hourly till 6th hour & 12th hourly & 24th hour.)