Coma Outcome in Early Neurological Rehabilitation: A Prospective Registry of Long-Term Outcome in Patients with Severe Disorders of Consciousness After Acute Brain Injury
- Conditions
- R40.2Coma, unspecified
- Registration Number
- DRKS00009609
- Lead Sponsor
- eurologische Klinik, Klinikum der LMU München
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 247
Inclusion Criteria
Acute brain injury as for the referral to a rehabilitation facility.
A disorder of consciousness at admission, defined as coma, vegetative state or MCS (based on the Coma Recovery Scale - Revised scores).
Written informed consent from caregivers or legal guardian.
Patient/Caregiver/Legal Guardian have a sufficient command of the German language and place of residence in Germany.
Exclusion Criteria
Application of continuous intravenous sedative drugs (e.g., benzodiazepines, propofol) for artificial coma
Study & Design
- Study Type
- observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method ong-term outcome (after 6, 12, 24, 36 months) of initially comatose patients with a severe brain injury that considers functional status, quality of life and life participation, after they had used consistently neurorehabilitative options available to them.
- Secondary Outcome Measures
Name Time Method The prognostic value of neurorehabilitation factors in the prediction of a long-term outcome and the psychosocial situation of caregivers.
Related Research Topics
Explore scientific publications, clinical data analysis, treatment approaches, and expert-compiled information related to the mechanisms and outcomes of this trial. Click any topic for comprehensive research insights.
What neurobiological pathways correlate with long-term recovery in severe disorders of consciousness post-acute brain injury?
How does early neurological rehabilitation impact functional outcomes in R40.2 coma patients compared to standard care protocols?
Which prognostic biomarkers are associated with favorable outcomes in the KOPF-R registry for post-traumatic coma patients?
What are the most common complications observed in long-term coma recovery following acute brain injury in the KOPF-R study?
What pharmacological agents or neurostimulation techniques are being evaluated alongside rehabilitation for disorders of consciousness in the eurologische Klinik cohort?