Trait Anxiety and Defensive Networks

Not Applicable

Completed

• Conditions: Healthy
• Interventions: Behavioral: trait anxiety scale; Drug: Placebo; Drug: Oxytocin

• Registration Number: NCT02682888
• Lead Sponsor: University of Electronic Science and Technology of China

Brief Summary

to examine the association between trait and defensive network connectivity and the modulatory effect of oxytocin on it

Detailed Description

Individuals with high trait anxiety show stable anxiety proneness even in the absence of real threat, which could be a result of intrinsic hyper-connectivity in the defensive systems. In the present study, healthy subjects' trait anxiety levels will be assessed by the sub-trait inventory of the State-Trait Anxiety Inventory. Then two experiments using resting-state fMRI technique will be conducted to first map how hubs in the defensive systems organized in high anxious individuals in a stimuli-free situation (Experiment 1) and then we will examine the modulatory effect of the intranasal administration of oxytocin on functional connectivity in these independently defined defensive networks (Experiment 2).

Study Timeline

• Study Start: 2015-12-08
• Study First Submitted: 2016-02-08
• Study First Submitted QC: 2016-02-16
• Study First Posted: 2016-02-17
• Primary Completion: 2021-08-19
• Study Completion: 2021-11-20
• Status Verified: 2022-02
• Last Update Submitted: 2022-02-10
• Last Update Posted: 2022-02-11

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 131

Inclusion Criteria

• Healthy subjects without past or current psychiatric or neurological disorders

Exclusion Criteria

• females should not be pregnant or during menstruation.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
high trait anxiety group	trait anxiety scale	experiment 1: identified according to scores of the trait anxiety scale.
placebo control group	Placebo	experiment 2: intranasal administration of placebo
low trait anxiety group	trait anxiety scale	experiment 1: identified according to scores of the trait anxiety scale.
oxytocin group	Oxytocin	experiment 2: intranasal administration of oxytocin

Primary Outcome Measures

Name	Time	Method
the resting state functional connectivity changes in the defensive network	one day	The resting-state activity can be accessed using functional magnetic resonance imaging (fMRI) by measuring spontaneous and low-frequency fluctuations (\< 0.1 Hz) when the brain is at rest. Group differences will be calculated in the high trait anxiety group relative to the low trait anxiety group and in the oxytocin group relative to the placebo group.

Trial Locations

Locations (1)

school of life science and technology, University of Electronic Science and Technology of China; 🇨🇳 Chengdu, Sichuan, China