To Determine the Effect of Remifentanil Dose on the Onset Time of Rocuronium Using TOF (Train-of-Four) Neuromuscular Monitoring in Patients Undergoing General Anaesthesia
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 75
- 试验地点
- 1
- 主要终点
- To determine the times taken to reach TOF 0 and TOFR 25% in groups R 0.5, R1 and S and to compare the results and therefore determine the optimal dose of Remifentanil infusion.
研究概览
简要总结
The sympathetic surge of hypertension and tachycardia following laryngoscopy and intubation are well known and extensively described. Opioids or other intravenous and inhalational agents are used to attenuate this potentially harmful effect. Opioids potentiate the action of muscle relaxants. Recently, Remifentanil was reported to have conflicting effect on onset time of Rocuronium.We want to study the effect of two different doses of Remifentanil as given by infusion, on the time taken to onset of action of Rocuronium for endotracheal intubation by monitoring with Train-of-Four (TOF).
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 盲法
- Participant Blinded
入排标准
- 年龄范围
- 18.00 Year(s) 至 60.00 Year(s)（—）
- 性别
- All
入选标准
- •Patients planned for any surgery requiring endotracheal intubation under general anaesthesia
- •Patients aged between 18 to 60 years
- •Patients with ASA grade I and II
- •Patients giving informed written consent.
排除标准
- •Patients with a history of cardiac, pulmonary, renal, hepatic, cerebral or neuromuscular disease
- •Having an allergy to opioids or propofol
- •Chronic alcohol or drug abuse
- •A body mass index of 30 kg/m2
- •Pregnant patients
- •Age less than 18 years or more than 60 years.
结局指标
主要结局
To determine the times taken to reach TOF 0 and TOFR 25% in groups R 0.5, R1 and S and to compare the results and therefore determine the optimal dose of Remifentanil infusion.
时间窗: TOF baseline, TOFR 25% and TOF 0
次要结局
- To monitor hemodynamic response to laryngoscopy and intubation.(Recorded at Baseline, at TOFR 25% and TOF 0)
研究者
Avni Sharma
KPC Medical College & Hospital