Spectral Characteristics of Memory Transformation

Not Applicable

Recruiting

• Conditions: Healthy

• Registration Number: NCT05946616
• Lead Sponsor: Medical University of South Carolina

Brief Summary

Sometimes, it is necessary to re-learn a previously learned movement behavior, for example, a bad posture during the golf drive or while playing the piano. Unlearning or relearning an intensively trained behavior is particularly important if the behavior is hampering recovery, for example, in chronic pain or after a stroke. With this pilot study, the brain mechanisms that control the change of pre-existing stable memories of a motor skill will be tested with electroencephalography (EEG). Non-invasive brain stimulation will be used to modulate these brain mechanisms and test if it is possible to change the pre-existing motor memory and the learning of a new motor skill.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2023-06-30
• Study Start: 2023-07-01
• Study First Submitted QC: 2023-07-07
• Study First Posted: 2023-07-14
• Status Verified: 2024-10
• Last Update Submitted: 2025-02-25
• Last Update Posted: 2025-02-28
• Primary Completion: 2025-12-31
• Study Completion: 2025-12-31

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

• Age 18 years or older (2/3 of the final sample will be ≥60years of age)
• No previous stroke, brain tumor, neurodegenerative disease, or trauma to the head
• Ability to give consent for study participation
• who have access to a personal computer with internet

Exclusion Criteria

• • Pregnancy

  • Inability to use all ten fingers to type on a standard computer keyboard
  • Uncorrected vision, hindering perception of visual cues presented on a standard computer screen
  • Medication use at the time of study that may interfere with learning or the effect of tACS, including but not limited to carbamazepine, flunarizine, sulpiride, rivastigmine, dextromethorphan;
  • Neuromuscular disorders affecting hand and finger movements necessary for 10-finger keyboard typing
  • Presence of neurological or psychiatric disorders
  • Presence of scalp injury or disease
  • Prior history of seizures
  • Prior intracranial surgery
  • Prior brain radiotherapy
  • Prior history of intracranial tumor, intracranial infection, or cerebrovascular malformation
  • Metal in head or neck
  • Contraindications to MRI (such as severe claustrophobia, implanted medical devices)

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Primary Outcome Measures

Name	Time	Method
Behavioral: interference rate	before - after one single intervention (1 hour)	Change in performance precision of a previously learned sensorimotor skill
Neural: brain connectivity change	before - after one single intervention (1 hour)	Change in EEG-derived markers of brain activation and connectivity

Secondary Outcome Measures

Name	Time	Method
Behavioral: interference rate	before - after one single intervention (24 hour follow-up)	Change in performance precision of a previously learned sensorimotor skill
Neural: brain connectivity change	before - after one single intervention (24 hour follow-up)	Change in EEG-derived markers of brain activation and connectivity

Trial Locations

Locations (1)

Medical University of South Carolina; 🇺🇸 Charleston, South Carolina, United States