Effect of Stress on Heroin-Related Memory Retrieval

Not Applicable

Completed

• Conditions: Heroin Dependence; Learning and Memory
• Interventions: Drug: propranolol and cortisol

• Registration Number: NCT00759005
• Lead Sponsor: National Institute on Drug Dependence, China

Brief Summary

The purpose of this study is to determine whether cortisol and propranolol are effective in the modulation of stress induced heroin-related retrieval enhancement.

Detailed Description

Not available

Study Timeline

• Study Start: 2007-03
• Primary Completion: 2008-06
• Status Verified: 2008-09
• Study Completion: 2008-09
• Study First Submitted: 2008-09-23
• Study First Submitted QC: 2008-09-23
• Last Update Submitted: 2008-09-23
• Study First Posted: 2008-09-25
• Last Update Posted: 2008-09-25

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Male
• Target Recruitment: Not specified

Inclusion Criteria

• Participants had to have met DSM-IV criteria for heroin dependence prior to abstinence.

Exclusion Criteria

• current use of any medications; current DSM-IV diagnosis of any affective, anxiety, or psychotic disorder; current dependence on any substance besides heroin and nicotine (based on DSM-IV criteria); or risk factors for untoward side effects from propranolol and cortisol (i.e., irregular heartbeats, history of cardiogenic shock, history of severe heart failure, asthma, fungal Infections, hyperlipidemia, history of hypertension, or abnormal ECG or other laboratory findings).

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
A, 4	propranolol and cortisol	-

Primary Outcome Measures

Name	Time	Method
Glucocorticoids enhanced heroin-related memory retrieval in abstained heroin addicts

Trial Locations

Locations (1)

National Institute on Drug Dependence; 🇨🇳 Beijing, Beijing, China