Comparison of efficacy of intrathecal bupivacaine heavy (0.5%) and levobupivacaine heavy (0.5%) for elective caesarean section
试验速览
- 阶段
- 4 期
- 状态
- 尚未招募
- 发起方
- 入组人数
- 60
- 试验地点
- 1
- 主要终点
- The onset of action
研究概览
简要总结
Bupivacaine is the most commonly used drug for spinal anaesthesia. Plain Bupivacaine is hypobaric compared to CSF and is made heavy by addition of 8% glucose.
It is known to cause hypotension, bradycardia even sudden cardiac death. Levobupivacaine is pure enantiomer of bupivacaine and is truly isobaric with CSF of pregnant women. It causes less cardiotoxicity and is more specific for sensory blockade than motor blockade.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 盲法
- Participant Blinded
入排标准
- 年龄范围
- 18.00 Year(s) 至 30.00 Year(s)（—）
- 性别
- Female
入选标准
- •Age 18-30 years ASA grading I and II Elective caesarean section surgical section.
排除标准
- •Patient who refused to give consent.
- •A Documented sensitivity to drug in the past.
- •Age less than 18 and more than
- •ASA grading III and IV.
- •Patient on anti hypertensive, anxiolytics, and anti epileptic.
- •Morbidly obese.
- •Patients for emergency lscs.
- •Patients with neurological and psychiatric illness.
- •Patients with spinal deformity.
- •Local site infections.
结局指标
主要结局
The onset of action
时间窗: Measured for half an hour every five minutes
Duration of sensory blockade
时间窗: Measured for half an hour every five minutes
Duration of motor blockade
时间窗: Measured for half an hour every five minutes
Quality of anaesthesia
时间窗: Measured for half an hour every five minutes
Hemodynamic alterations
时间窗: Measured for half an hour every five minutes
Adverse effects
时间窗: Measured for half an hour every five minutes
次要结局
- Pruritus(Sedation)
研究者
Anagha V Harlapur
BJGMC and Sassoon hospital